3528-45-8

Basic information

• Product Name: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
• Synonyms: TIMTEC-BB SBB011062;2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE;1H-pyrazol-5-amine, 1-[(4-methoxyphenyl)methyl]-;2-[(4-Methoxyphenyl)Methyl]pyrazol-3-aMine;2-(4-Mehoxy-benzyl)-2H-pyrazol-3-ylamine;[2-(4-methoxybenzyl)pyrazol-3-yl]amine;2-[(4-methoxyphenyl)methyl]-3-pyrazolamine;1-[(4-Methoxyphenyl)methyl]-1H-pyrazol-5-amine
• CAS NO: 3528-45-8
• Molecular Formula: C₁₁H₁₃N₃O
• Molecular Weight: 203.24
• Mol File: 3528-45-8.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE(3528-45-8)
• EPA Substance Registry System: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE(3528-45-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 3528-45-8(Hazardous Substances Data)

Usage

Description

2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE is an organic compound with the chemical formula C11H12N2O. It is a white crystalline solid and is commonly used as a synthesis intermediate for various compounds, particularly in the pharmaceutical industry. 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE is known for its potential applications in the development of new drugs and has been identified as a useful research chemical.

Uses

Used in Pharmaceutical Industry:
2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE is used as a synthesis intermediate for the development of new medicaments. Its unique chemical structure allows it to be a key component in the creation of various pharmaceutical compounds, contributing to the advancement of drug discovery and innovation.
Used in Research and Development:
As a research chemical, 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE plays a crucial role in the study and understanding of various chemical reactions and processes. It is utilized by researchers to explore new synthetic pathways, develop novel drug candidates, and gain insights into the structure-activity relationships of different compounds.

InChI:InChI=1S/C11H13N3O/c1-15-10-4-2-9(3-5-10)8-14-11(12)6-7-13-14/h2-7H,8,12H2,1H3

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 227617-24-5 2-(4-methoxy-benzyl)-2H-pyrazol-3-yl-amine monohydrochloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 107-13-1 acrylonitrile 
• 353-07-1 3-hydrazinylpropanenitrile 
• 64841-16-3 3-{N'-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-hydrazino}-propionitrile 
• 7803-57-8 hydrazine hydrate 

Downstream Products

• 227617-22-3 5-benzoyl-1-(4-methoxy-benzyl)-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one 
• 227617-15-4 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 949556-46-1 5-(((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 924909-16-0 1-(4-methoxy-benzyl)-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one 
• 370866-01-6 5-Bromo-4-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine 
• 370866-02-7 5-bromo-4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine 
• 370865-99-9 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 227617-16-5 ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 
• 370866-03-8 5-Bromo-4-butoxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo [3,4-b]pyridine 
• 227617-17-6 4-Butoxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 370866-04-9 4-butoxy-1-(4-methoxy-benzyl)-5-phenylsulfanyl-1H-pyrazolo[3,4-b]pyridine 
• 227617-18-7 4-Butoxy-N-methoxy-1-[(4-methoxyphenyl)methyl]-N-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 582315-56-8 4-butoxy-1-(4-methoxy-benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethylamide 
• 227617-23-4 (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone 

Relevant articles and documents

Growth Factor Receptor antagonists. Preparation method and application thereof

The invention relates to a small molecule antagonist for transforming growth factor β receptors, a method for preparing the small molecule antagonist, and application of the small molecule antagonist in preparation of drugs. The small molecule antagonist for transforming the growth factor β receptor has the application of treating and/or preventing various diseases mediated by ALK5, and has great clinical application potential.

INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to 1 H-pyrazolo[3,4-b]pyridine compounds of the formula (I) in which R1, R2, R3 and R4 are defined as indicated below. The compounds of the formula I are protein kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.