370866-02-7

Basic information

• Product Name: 1H-Pyrazolo[3,4-b]pyridine, 5-bromo-4-chloro-1-[(4-methoxyphenyl)methyl]-
• CAS NO: 370866-02-7
• Molecular Formula: C14H11BrClN3O
• Molecular Weight: 352.618
• Mol File: 370866-02-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazolo[3,4-b]pyridine, 5-bromo-4-chloro-1-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazolo[3,4-b]pyridine, 5-bromo-4-chloro-1-[(4-methoxyphenyl)methyl]-(370866-02-7)
• EPA Substance Registry System: 1H-Pyrazolo[3,4-b]pyridine, 5-bromo-4-chloro-1-[(4-methoxyphenyl)methyl]-(370866-02-7)

Safety Data

• Hazardous Substances Data: 370866-02-7(Hazardous Substances Data)

Upstream product

• 1034770-08-5 5-bromo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4(7H)-one 
• 227617-15-4 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 370865-99-9 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 3528-45-8 1-(4-methoxybenzyl)-1H-pyrazol-5-amine 
• 370866-01-6 5-Bromo-4-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine 

Downstream Products

• 1034769-89-5 tert-butyl (4-(5-bromo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl)methylcarbamate 
• 1174913-74-6 benzyl (R)-(4-(5-bromo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl)methylcarbamate 
• 370866-03-8 5-Bromo-4-butoxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo [3,4-b]pyridine 
• 370866-04-9 4-butoxy-1-(4-methoxy-benzyl)-5-phenylsulfanyl-1H-pyrazolo[3,4-b]pyridine 
• 370866-05-0 4-butoxy-5-phenylsulfanyl-1H-pyrazolo[3,4-b]pyridine 

Relevant articles and documents

Identification of inhibitors of checkpoint kinase 1 through template screening

Checkpoint kinase 1 (CHK1) is an oncology target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment

1H-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: Highly potent 2,6-difluorophenacyl analogues

Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC50=6 nM, CDK2/cycE IC50=9 nM). The 2,6-difluorophenyl substitution was cri