370865-99-9Relevant articles and documents
Growth Factor Receptor antagonists. Preparation method and application thereof
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Paragraph 0133-0134; 0147-0150, (2021/11/27)
The invention relates to a small molecule antagonist for transforming growth factor β receptors, a method for preparing the small molecule antagonist, and application of the small molecule antagonist in preparation of drugs. The small molecule antagonist for transforming the growth factor β receptor has the application of treating and/or preventing various diseases mediated by ALK5, and has great clinical application potential.
MULTIKINASE INHIBITOR
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Page/Page column 36-37, (2008/12/05)
It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents -(O)n-R; R represents a C1-C6 alkyl group or the like; n represents 0 or 1; X represents O or the like; R2, R3 and R4 are independently selected from a hydrogen atom or C1-C3 alkyl; or R2 and R3 may join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.
Use of 5-thio-, sulfinyl- and sulfonylpyrazolo[3,4-b]- pyridines as cyclin dependent kinase inhibitors
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, (2008/06/13)
The present invention describes compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and n are as defined above. Compounds of formula (I) are protein kinase inhibitors