924909-16-0

Basic information

• Product Name: 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-Methoxyphenyl)Methyl]-
• Synonyms: 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-Methoxyphenyl)Methyl]-
• CAS NO: 924909-16-0
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.27192
• Mol File: 924909-16-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-Methoxyphenyl)Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-Methoxyphenyl)Methyl]-(924909-16-0)
• EPA Substance Registry System: 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-Methoxyphenyl)Methyl]-(924909-16-0)

Safety Data

• Hazardous Substances Data: 924909-16-0(Hazardous Substances Data)

Usage

Description

1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]-, also known as 4-methoxyphenylmethyl 1H-pyrazolo[3,4-b]pyridin-4-ol, is a heterocyclic chemical compound with the molecular formula C16H14N2O2. It features a pyrazole ring fused to a pyridine ring, with a hydroxyl group at the 4th position and a 4-methoxyphenylmethyl substituent attached to the nitrogen of the pyrazole ring. 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]may have potential pharmaceutical and medicinal applications, but further research and testing are required to determine its specific uses and properties.

Uses

Used in Pharmaceutical Industry:
1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]is used as a potential pharmaceutical candidate for the development of new drugs due to its unique molecular structure and heterocyclic nature, which may offer novel therapeutic properties and mechanisms of action.
Used in Medicinal Chemistry Research:
1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]is used as a starting material or a scaffold in medicinal chemistry research for the design and synthesis of new molecules with potential therapeutic applications. Its heterocyclic structure and functional groups can be modified to explore various biological activities and optimize its pharmacological profile.

Upstream product

• 370865-99-9 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 3528-45-8 1-(4-methoxybenzyl)-1H-pyrazol-5-amine 
• 227617-15-4 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 949556-46-1 5-(((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 123-11-5 4-methoxy-benzaldehyde 
• 227617-24-5 2-(4-methoxy-benzyl)-2H-pyrazol-3-yl-amine monohydrochloride 

Downstream Products

• 370866-01-6 5-Bromo-4-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine 
• 370866-03-8 5-Bromo-4-butoxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo [3,4-b]pyridine 
• 370866-04-9 4-butoxy-1-(4-methoxy-benzyl)-5-phenylsulfanyl-1H-pyrazolo[3,4-b]pyridine 
• 949556-47-2 4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine 
• 949558-01-4 1-(4-methoxybenzyl)-4-(5-chloro-2-methyl-4-nitrophenoxy)-1H-pyrazolo[3,4-b]pyridine 
• 924909-17-1 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine 
• 1173068-76-2 tert-butyl 4-(1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate 
• 1173069-44-7 5-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol 
• 29274-28-0 4-Chloro-1H-pyrazolo<3,4-b>pyridine 
• 1357945-38-0 3-bromo-4-chloro-1H-pyrazolo[3,4-b]pyridine 
• 949558-30-9 4-chloro-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 949558-31-0 4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3 ,4-b]pyridine 

Relevant articles and documents

Growth Factor Receptor antagonists. Preparation method and application thereof

The invention relates to a small molecule antagonist for transforming growth factor β receptors, a method for preparing the small molecule antagonist, and application of the small molecule antagonist in preparation of drugs. The small molecule antagonist for transforming the growth factor β receptor has the application of treating and/or preventing various diseases mediated by ALK5, and has great clinical application potential.

INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS

Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.