22785-43-9 Usage
Description
S-3-N-Cbz-amino-2,6-Dioxo-piperidine, also known as (S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a benzyl group, a carbamate functional group, and a 2,6-dioxopiperidine ring. S-3-N-Cbz-amino-2,6-Dioxo-piperidine plays a significant role in the development of therapeutic agents, particularly in the field of oncology.
Uses
Used in Pharmaceutical Industry:
S-3-N-Cbz-amino-2,6-Dioxo-piperidine is used as a key intermediate in the synthesis of Lenalidomide, an important drug used for the treatment of multiple myeloma and myelodysplastic syndromes. Its unique structure allows for the formation of essential chemical bonds and reactions that are necessary for the production of Lenalidomide, making it a vital component in the pharmaceutical industry.
Used in Oncology Research:
As a precursor to Lenalidomide, S-3-N-Cbz-amino-2,6-Dioxo-piperidine contributes to the development of therapeutic agents that target various types of cancer. Lenalidomide, the final product, has been shown to have immunomodulatory and anti-angiogenic properties, making it effective against multiple myeloma and other malignancies. The compound's role in the synthesis of such a potent drug highlights its importance in oncology research and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 22785-43-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,7,8 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22785-43:
(7*2)+(6*2)+(5*7)+(4*8)+(3*5)+(2*4)+(1*3)=119
119 % 10 = 9
So 22785-43-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2O4/c16-11-7-6-10(12(17)15-11)14-13(18)19-8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,14,18)(H,15,16,17)/t10-/m0/s1
22785-43-9Relevant articles and documents
Preparation method of deuterated intermediate
-
, (2018/11/03)
The present invention provides a preparation method of a deuterated intermediate. The deuterated intermediate has a structure shown by a formula I; the preparation method comprises the following steps: amino groups in a raw material A and an aldehyde grou
METHODS FOR THE TREATMENT OF LOCALLY ADVANCED BREAST CANCER
-
Page/Page column 57, (2014/03/26)
Provided herein are methods of treating, preventing and/or managing locally advanced breast cancer, including inflammatory breast cancer, which comprise administering to a patient one or more immunomodulatory compounds or enantiomers or mixtures of enantiomers thereof, or pharmaceutically acceptable salts, solvates, hydrates, co-crystals, clathrates, or polymorphs thereof.
Synthesis of (-)-julocrotine and a diversity oriented Ugi-approach to analogues and probes
Neves Filho, Ricardo A. W.,Westermann, Bernhard,Wessjohann, Ludger A.
supporting information; experimental part, p. 1504 - 1507 (2012/01/06)
An improved total synthesis of (-)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (-)-julocrotine analogues was synthesized by employing the heterocyclic precursor as an amino input in Ugi four-component reactions (Ugi-4CR) [1].
