22802-00-2 Usage
Description
2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium, also known as a diazeniumdiolate or NONOate, is a chemical compound with potential pharmaceutical applications. It is a nitric oxide donor, which means it can release nitric oxide when it comes into contact with biological tissues. Nitric oxide is a crucial signaling molecule in the human body, playing a role in various physiological processes such as vasodilation, neurotransmission, and immune response. The acetyloxy and dimethoxy groups attached to the phenyl ring contribute to the compound's stability and solubility, making it a promising candidate for drug development.
Uses
Used in Cardiovascular Applications:
2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium is used as a nitric oxide donor for the treatment of cardiovascular diseases. 2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium's ability to release nitric oxide can help in vasodilation, improving blood flow and reducing the risk of heart attacks and strokes.
Used in Pulmonary Hypertension Applications:
In the treatment of pulmonary hypertension, 2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium is used as a nitric oxide donor to help relax the smooth muscle in blood vessels, leading to reduced blood pressure in the lungs and improved oxygenation.
Used in Cancer Therapy Applications:
2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium is used as a potential therapeutic agent in cancer treatment. 2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium's nitric oxide-releasing property can help in inducing apoptosis in cancer cells, inhibiting tumor growth, and enhancing the effectiveness of conventional chemotherapy and radiation therapies.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[4-(acetyloxy)-3,5-dimethoxyphenyl]-2-oxoethylidenediazenium is used as a key compound in the development of new drugs targeting various diseases. Its unique properties as a nitric oxide donor and its stability make it an attractive candidate for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 22802-00-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,8,0 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22802-00:
(7*2)+(6*2)+(5*8)+(4*0)+(3*2)+(2*0)+(1*0)=72
72 % 10 = 2
So 22802-00-2 is a valid CAS Registry Number.
22802-00-2Relevant articles and documents
2-Diazo-1-(4-hydroxyphenyl)ethanone: A versatile photochemical and synthetic reagent
Senadheera, Sanjeewa N.,Evans, Anthony S.,Toscano, John P.,Givens, Richard S.
, p. 324 - 341 (2014/02/14)
α-Diazo arylketones are well-known substrates for Wolff rearrangement to phenylacetic acids through a ketene intermediate by either thermal or photochemical activation. Likewise, α-substituted p-hydroxyphenacyl (pHP) esters are substrates for photo-Favorskii rearrangements to phenylacetic acids by a different pathway that purportedly involves a cyclopropanone intermediate. In this paper, we show that the photolysis of a series of α-diazo-p- hydroxyacetophenones and p-hydroxyphenacyl (pHP) α-esters both generate the identical rearranged phenylacetates as major products. Since α-diazo-p-hydroxyacetophenone (1a, pHP N2) contains all the necessary functionalities for either Wolff or Favorskii rearrangement, we were prompted to probe this intriguing mechanistic dichotomy under conditions favorable to the photo-Favorskii rearrangement, i.e., photolysis in hydroxylic media. An investigation of the mechanism for conversion of 1a to p-hydroxyphenyl acetic acid (4a) using time-resolved infrared (TRIR) spectroscopy clearly demonstrates the formation of a ketene intermediate that is subsequently trapped by solvent or nucleophiles. The photoreaction of 1a is quenched by oxygen and sensitized by triplet sensitizers and the quantum yields for 1a-c range from 0.19 to a robust 0.25. The lifetime of the triplet, determined by Stern-Volmer quenching, is 31 ns with a rate for appearance of 4a of k = 7.1 × 10 6 s-1 in aq. acetonitrile (1:1 v:v). These studies establish that the primary rearrangement pathway for 1a involves ketene formation in accordance with the photo-Wolff rearrangement. Furthermore we have also demonstrated the synthetic utility of 1a as an esterification and etherification reagent with a variety of substituted α-diazo-p- hydroxyacetophenones, using them as synthons for efficiently coupling it to acids and phenols to produce pHP protect substrates. The Royal Society of Chemistry and Owner Societies.