39657-47-1Relevant articles and documents
NOVEL α-TOCOPHEROL DERIVATIVES, AND COSMETIC USES OF THE SAME
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Paragraph 0089-0092, (2019/07/03)
The present invention relates to a novel andalpha;-tocopherol derivative compound and cosmetic uses thereof, more specifically, a compound represented by chemical formula 1. The present invention has an antioxidant activity as a novel compound and inhibits the activity of elastase, which is a degradation enzyme of elastin protein related to wrinkle formation of skin, thereby having an effect of alleviating skin wrinkles. In the chemical formula 1, n is 3, and R_1 is each independently hydrogen, a methyl group, or an acetyl group.COPYRIGHT KIPO 2019
NOVEL PHENOLIC ACID DERIVATIVES, AND USES OF THE SAME
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Paragraph 0103; 0106; 0107, (2018/03/09)
The present invention relates to a novel phenolic acid-type derivative compound having whitening and antioxidant activities and a use thereof, and more specifically, to a compound represented by chemical formula 1 below, an isomer thereof, or a salt thereof. Compounds according to the present invention have a tyrosinase-inhibiting skin whitening activity and therefore can be beneficially used in a skin-whitening pharmaceutical composition or cosmetic product, and also have an antioxidant activity and therefore can be used beneficially to prevent or treat skin aging. In the chemical formula 1, n is 0 or 1; X is NH or S; Y is an alkyl group having 1-2 carbon atoms; R is a hydroxyl alkyl, hydroxyl aryl, or hydroxyl alkylaryl group having 1-8 carbon atoms, an amino group, or an amide group; R_2 is H or an alkyl group having 1-3 carbon atoms; and R_3 is H or a methyl group.COPYRIGHT KIPO 2016
Synthesis of selective butyrylcholinesterase inhibitors coupled between α-lipoic acid and polyphenols by using 2-(piperazin-1-yl)ethanol linker
Yeun, Go Heum,Lee, Seung Hwan,Lim, Yong Bae,Lee, Hye Sook,Won, Moo-Ho,Lee, Bong Ho,Park, Jeong Ho
, p. 1025 - 1029 (2013/07/28)
In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between a-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2-aminoethoxy)ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy)ethanol (linker 1) was switched to the cationic 2-(piperazin-1-yl)ethanol linker (linker 2). The IC50 values of the linker-2 hybrid molecules for BuChE inhibition were lower than those of linker-1 hybrid molecules (except 9-2) and they also had the same great selectivity for BuChE over AChE (> 800 fold) as linker-1 hybrid molecules. ALA-acetyl caffeic acid (10- 2, ALA-AcCA) was shown as an effective inhibitor of BuChE (IC50 = 0.44 ± 0.24 μM). A kinetic study using 7- 2 showed that it is the same mixed type inhibition as 7-1. Its inhibition constant (Ki) to BuChE is 4.3 ± 0.09 μM.