22802-67-1

Basic information

• Product Name: methyl 5-amino-o-anisate
• Synonyms: methyl 5-amino-o-anisate;2-Methoxy-5-aminobenzoic acid methyl ester;methyl 5-azanyl-2-methoxy-benzoate;4-Amino-2-(methoxycarbonyl)anisole, 4-Methoxy-3-(methoxycarbonyl)aniline;Benzoic acid, 5-aMino-2-Methoxy-, Methyl ester
• CAS NO: 22802-67-1
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.18854
• EINECS: 245-230-4
• Product Categories: Aromatic Esters;Esters;Phenyls & Phenyl-Het
• Mol File: 22802-67-1.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 329.6 °C at 760 mmHg
• Flash Point: 173.3 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.000175mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.05±0.10(Predicted)
• CAS DataBase Reference: methyl 5-amino-o-anisate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-amino-o-anisate(22802-67-1)
• EPA Substance Registry System: methyl 5-amino-o-anisate(22802-67-1)

Safety Data

• Hazardous Substances Data: 22802-67-1(Hazardous Substances Data)

Usage

General Description

Methyl 5-amino-o-anisate is a chemical compound that is derived from anisole, an aromatic compound found in essential oils. It is a white crystalline powder with a molecular formula C9H11NO3. Methyl 5-amino-o-anisate has a variety of uses, including as an intermediate in the production of pharmaceuticals and as a fragrance ingredient in perfumes and personal care products. It is also used as a raw material in the synthesis of organic compounds, particularly for the manufacture of dyes and pigments. Additionally, it has shown potential as an anti-inflammatory agent in medical research. Overall, methyl 5-amino-o-anisate has multiple applications in various industries and fields.

InChI:InChI=1/C9H11NO3/c1-12-8-4-3-6(10)5-7(8)9(11)13-2/h3-5H,10H2,1-2H3

Upstream product

• 34841-11-7 methyl 2-methoxy-5-nitrobenzoate 
• 180690-86-2 methyl 5-<(tert-butoxycarbonyl)amino>-2-methoxybenzoate 
• 17302-46-4 methyl 2-hydroxy-5-nitrobenzoate 
• 42753-75-3 methyl 5-amino-2-hydroxybenzoate 
• 77-78-1 dimethyl sulfate 
• 89-56-5 5-Methylsalicylic acid 
• 606-45-1 2-methoxybenzoic acid methyl ester 
• 40751-89-1 2-methoxy-5-nitrobenzoic acid 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 67-56-1 methanol 
• 96-97-9 5-nitrosalicylic acid 
• 3403-47-2 3-amino-6-methoxy-benzoic acid 

Downstream Products

• 151391-84-3 5-{[1-(2,5-Dihydroxy-phenyl)-meth-(E)-ylidene]-amino}-2-methoxy-benzoic acid methyl ester 
• 68256-19-9 methyl 2-methoxy-5-methanesulfonamidobenzoate 
• 90763-20-5 C₁₁H₁₆N₂O₅S 
• 185808-83-7 5-(2-bromo-2-methoxycarbonyl-ethyl)-2-methoxy-benzoic acid methyl ester 
• 79893-19-9 methyl 5-(acetylamino)-o-anisate 
• 135-95-5 3-hydroxymethyl-4-methoxyaniline 
• 1013068-79-5 C₁₂H₁₅NO₃ 
• 943513-53-9 C₃₃H₃₄FN₃O₅ 
• 185808-79-1 5-[(2,4-Dioxothiazolidin-5-yl)methyl]-2-methoxybenzoic acid 
• 186312-73-2 methyl 5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-benzoate 
• 213252-19-8 N-(4-trifluoromethylbenzyl)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxybenzamide 
• 370559-52-7 methyl 2-methoxy-5-trifluoroacetylamidobenzoate 
• 475596-40-8 methyl 2-methoxy-5-[3-(4-(5-phenylpentyloxy)phenyl)propanoylamino]benzoate 
• 168267-86-5 2-methoxy-5-(tetrazol-1-yl)-benzoic acid,methyl ester 

Relevant articles and documents

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EIF4E INHIBITORS AND USES THEREOF

The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.

Folding and Assembly of Short α, β, ?-Hybrid Peptides: Minor Variations in Sequence and Drastic Differences in Higher-Level Structures

Multilevel protein structures typically involve polypeptides of sufficient lengths. Here we report the folding and assembly of seven short tetrapeptides sharing the same types of α-, β-, and aromatic ?-amino acid residues. These are two sets of hybrid peptides, with three members in one set and four in the other, having complementary hydrogen-bonding sequences that were hypothesized to pair into linear H-bonded duplexes. However, instead of undergoing the anticipated pairing, the initially examined three oligomers, 1 and 2a or 2b, differing only in their central αβ hybrid dipeptide sequence, do not associate with each other and exhibit distinctly different folding behavior. Experiments based on NMR and mass spectrometry, along with computational studies and systematic inference, reveal that oligomer 1 folds into an expanded β-turn containing an unusual hybrid α/β-amino acid sequence composed of glycine and β-alanine, two α- A nd β-amino acid residues that are conformationally most flexible, and peptides 2a and 2b adopt a noncanonical, extended helical conformation and dimerize into double helices undergoing rapid conformational exchange or helix inversion. The different central dipeptide sequences, αβ vs βα, result in drastically different intramolecular H-bonding patterns that are responsible for the observed folding behavior of 1 and 2. The revealed turn and double helix have few natural or synthetic counterparts, and provide novel and unique folding prototypes based on which chiral α- A nd β-amino acids are incorporated. The resultant derivatives 1a, 1b, 2c, and 2d follow the same folding and assembling behavior and demonstrate the generality of this system with the formation of expanded β-turns and double helices with enhanced folding stabilities, hampered helix inversion, as well as defined and dominant helical sense. This work has demonstrated the unique capability of synthetic foldamers in generating structures with fascinating folding and assembling behavior. The revealed systems offer ample opportunity for further structural optimization and applications.