23471-46-7 Usage
Description
1-(4-Chlorophenoxy)-2-propanaMine HCl, also known as meclizine hydrochloride, is a medication that belongs to the antihistamine class. It is primarily used to alleviate symptoms such as nausea, vomiting, and dizziness caused by motion sickness. Meclizine hydrochloride works by blocking the effects of histamine, a natural substance in the body that plays a role in allergic reactions. Furthermore, it possesses anticholinergic properties, which contribute to the reduction of dizziness and vertigo symptoms. The hydrochloride salt form of the chemical enhances its solubility and bioavailability, making it an effective treatment for motion sickness and related conditions.
Uses
Used in Pharmaceutical Industry:
1-(4-Chlorophenoxy)-2-propanaMine HCl is used as an antihistamine medication for the treatment of motion sickness. It is effective in managing symptoms such as nausea, vomiting, and dizziness by blocking the effects of histamine, a substance involved in allergic reactions.
1. Used in Motion Sickness Treatment:
Meclizine hydrochloride is used as a medication to alleviate the discomfort caused by motion sickness. It helps reduce the symptoms of nausea, vomiting, and dizziness, providing relief to individuals who experience these issues during travel.
2. Used in Vertigo and Dizziness Management:
Due to its anticholinergic properties, meclizine hydrochloride is also utilized in managing symptoms of dizziness and vertigo. It can help stabilize the individual's sense of balance and reduce the severity of these symptoms, improving their overall quality of life.
3. Used in Allergic Reaction Management:
As an antihistamine, meclizine hydrochloride can be employed to counteract the effects of histamine during allergic reactions. This can help alleviate symptoms such as itching, redness, and swelling, providing relief to those affected by allergies.
Check Digit Verification of cas no
The CAS Registry Mumber 23471-46-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,4,7 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 23471-46:
(7*2)+(6*3)+(5*4)+(4*7)+(3*1)+(2*4)+(1*6)=97
97 % 10 = 7
So 23471-46-7 is a valid CAS Registry Number.
23471-46-7Relevant articles and documents
2-(Arylthio)ethanamines and &α-(Arylthio)propionamides with Antidepressant Activity
Nair, M. D.,David, J.,Nagarajan, K.
, p. 940 - 947 (2007/10/02)
Reaction of aziridine with thiophenols affords 2-arylthioethanamines; with 2-methylaziridine, ring opening occurs regiospecifically to provide 1-arylthio-2-propanamines.The structure of one member of this group, 1-(4-chlorophenylthio)-2-propanamine (7), has been proved by other unambiguous syntheses. 7 and isomer 12 arise from the alkylation of 4-chlorothiophenol with 2-chloropropylamine as well as from the displacement of the tosyl group in 1-(4-chlorophenylthio)-2-tosyloxypropane (13).Alkylation of 4-chlorothiophenol with α-chloropropionamide affords 11 which leads to 12 on LAH reduction.Ethanamines and propanamines are converted into guanidines, amides, ureas and thioureas.Many arylthioethanamines, e.g. 7, 22, 28, 38 and 39 (as HCl salts) and α-arylthiopropionamides, e.g. 11, 86, 91, 93 and 96 exhibit good activity in the DOPA potentiation and reserpine antagonism tests.Among these, 7 HCl is the most potent and does not inhibit rat brain MAO activity.In clinical trials, C 2998-Go compares favourably with imipramine.
