2372-70-5 Usage
General Description
ISONIPECOTIC ACID, 1-ALLYL-4-PHENYL-, ETHYL ESTER is a chemical compound that is an ester derivative of isonipecotic acid, allyl, and phenyl. It is commonly used in organic synthesis and in the pharmaceutical industry. ISONIPECOTIC ACID, 1-ALLYL-4-PHENYL-, ETHYL ESTER has potential applications in the development of new drugs and medications, and it is also used as a reagent in chemical reactions. Its specific properties and potential uses may make it a valuable asset in various research and industrial settings. However, as with any chemical compound, it is important to handle it with care and ensure proper safety measures are in place during its handling and use.
Check Digit Verification of cas no
The CAS Registry Mumber 2372-70-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,7 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2372-70:
(6*2)+(5*3)+(4*7)+(3*2)+(2*7)+(1*0)=75
75 % 10 = 5
So 2372-70-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H23NO2/c1-3-12-18-13-10-17(11-14-18,16(19)20-4-2)15-8-6-5-7-9-15/h3,5-9H,1,4,10-14H2,2H3
2372-70-5Relevant articles and documents
Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine
Mercer, Susan L.,Hassan, Hazem E.,Cunningham, Christopher W.,Eddington, Natalie D.,Coop, Andrew
, p. 1160 - 1162 (2007/10/03)
P-Glycoprotein (P-gp) is an efflux transporter which is up-regulated at the blood-brain barrier in both morphine- and oxycodone-tolerant rats. Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-gp, suggesting that up-regulation of P-gp may contribute to the development of central tolerance to opioids. The studies herein focus on the development of SAR for P-gp substrate activity in the meperidine series of compounds, and show that a meperidine analog of greater potency, N-phenylbutyl-N-normeperidine, has low activity as a P-gp substrate and has the potential to be utilized as a tool to study the contribution of P-gp to the development of central tolerance to opioids.
