40481-13-8Relevant articles and documents
Muscarinic acetylcholine receptor binding affinities of pethidine analogs
Lee, Na-Ra,Zhang, Xuan,Darna, Mahesh,Dwoskin, Linda P.,Zheng, Guangrong
, p. 5032 - 5035 (2015/11/09)
A series of pethidine analogs were synthesized and their affinities for the [3H]N-methyl-scopolamine (NMS) binding site on muscarinic acetylcholine receptors (mAChRs) were determined using M1, M3 or M5 human mAChRs expressed by Chinese hamster ovary (CHO) cell membranes. Compound 6b showed the highest binding affinities at M1, M3 and M5 mAChRs (Ki = 0.67, 0.37, and 0.38 μM, respectively).
DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS
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, (2012/02/15)
The present invention relates to new drug combinations which contain in addition to one or more PDE4-inhibitors at least one NSAID (=non-steroidal anti-inflammatory drug) (2), processes for preparing them and their use in treating in particular respiratory complaints such as for example COPD, chronic sinusitis and asthma. The invention particularly relates to those drug combinations which contain, in addition to one or more, preferably one PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R1, R2, R3 and R4 have the meanings given in claim 1, at least one NSAID (2), the preparation thereof and the use thereof for the treatment of respiratory complaints.
METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
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Page 170; 171, (2008/06/13)
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.