2386-60-9 Usage
Description
1-Butanesulfonyl chloride is a chemical compound with the formula CH3CH2CH2CH2SO2Cl. It is a clear, colorless to light yellow liquid at room temperature and is commonly used in the synthesis of various organic compounds.
Uses
1. Used in Pharmaceutical Industry:
1-Butanesulfonyl chloride is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its application is due to its ability to react with amines to form sulfonamides, which are important in the development of drugs with diverse therapeutic properties.
2. Used in Chemical Synthesis:
1-Butanesulfonyl chloride is used as a reagent in the synthesis of various organic compounds, such as ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate, 1-butanesulfonamid-N,N′-1,2-ethanediylbis, and 1-butanesulfonamide-N,N′-1,3-propanediylbis. Its application in this field is attributed to its reactivity and versatility in forming different types of chemical bonds.
3. Used in Research and Development:
1-Butanesulfonyl chloride is utilized in research and development for the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals. Its use in this context is due to its unique chemical properties and the possibility of creating a wide range of products through its reactions.
Purification Methods
It has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.]
Check Digit Verification of cas no
The CAS Registry Mumber 2386-60-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,8 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2386-60:
(6*2)+(5*3)+(4*8)+(3*6)+(2*6)+(1*0)=89
89 % 10 = 9
So 2386-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13ClO3/c1-14-10-4-3-8(7-11(10)15-2)9(13)5-6-12/h3-4,7H,5-6H2,1-2H3
2386-60-9Relevant articles and documents
Quast,Kees
, p. 489 (1974)
Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides
Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao
, (2021/09/20)
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.
Unexpected distinction in reactivity of pentafluorobenzenesulfonyl halides toward organolithiums and organomagnesium halides
Bardin, Vadim V.,Maksimov, Alexander M.
, p. 731 - 737 (2017/10/16)
C6F5SO2Cl reacts with organolithiums and organomagnesium halides RM (R = Me, Bu, Ph; M = Li, MgX) to give mainly C6F5H and C6F5Cl. C6F5SO2Br and
Tert -Butyl Hypochlorite Mediated Oxidative Chlorination of S -Alkylisothiourea Salts: Synthesis of Sulfonyl Chlorides
Qiu, Kui,Wang, Rennan
, p. 3186 - 3190 (2015/10/19)
Under neutral conditions, a variety of S-alkylisothiourea salts were smoothly converted into the corresponding sulfonyl chlorides through tert-butyl chlorite mediated oxidative chlorination in good to excellent yields after simple purification. In addition to the environmental and procedural advantages of this method, the neutral conditions potentially make it applicable to substrates that bear acid-sensitive functional groups. For example, the Cbz-protected 2-aminoethanesulfonyl chloride could be synthesized in moderate to good yields under the current neutral conditions, and the acid-sensitive Cbz-protecting group was not affected.
