243139-85-7

Basic information

• Product Name: phenylmethyl 2-(cyclohexylcarbonylamino)acetate
• Synonyms: phenylmethyl 2-(cyclohexylcarbonylamino)acetate
• CAS NO: 243139-85-7
• Molecular Weight: 275.348
• Mol File: 243139-85-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: phenylmethyl 2-(cyclohexylcarbonylamino)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: phenylmethyl 2-(cyclohexylcarbonylamino)acetate(243139-85-7)
• EPA Substance Registry System: phenylmethyl 2-(cyclohexylcarbonylamino)acetate(243139-85-7)

Safety Data

• Hazardous Substances Data: 243139-85-7(Hazardous Substances Data)

Upstream product

• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 98-89-5 Cyclohexanecarboxylic acid 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 

Downstream Products

• 406954-91-4 N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide 
• 406954-89-0 1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 32377-88-1 (cyclohexanecarbonyl-amino)-acetic acid 

Relevant articles and documents

Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals

Bicyclization of peptide acetals via nucleophilic attack of a phenyl group on an endocyclic acyliminium ion 4 was explored as a route to novel amino acid derived heterocycles and peptidomimetic scaffolds. In the presence of protic acid, bridged structures such as 6 are formed readily from phenylalanine derivatives, but the fused-ring analogues 5 could not be obtained in good yield. In contrast, radical cyclization of the bromophenyl dihydropyrazinone 7 provides an effective alternative for the synthesis of 5 (n = 0, 1, 2). Additional versatility in this process was demonstrated by efficient synthesis of a different fused ring system, represented by the antihelmintic praziquantel, 8.