32377-88-1Relevant articles and documents
MAGL inhibitor and preparation method and application thereof
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Paragraph 0046-0048, (2020/08/30)
The invention belongs to the field of medicines, and relates to a compound and a pharmaceutically acceptable salt thereof, a preparation method thereof, intermediates for the preparation thereof, compositions containing the compounds or the salt, and thei
NOVEL BACTERIOSTATIC OR ANTIBACTERIAL AGENT
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Paragraph 0030, (2016/11/28)
PROBLEM TO BE SOLVED: To provide a food-derived bacteriostatic or antibacterial substance having effect on pathogenic bacteria, and a plant pathogen inhibitor and an infection preventive agent for humans, domestic animals and the like which comprise the same as an active ingredient. SOLUTION: This invention provides a novel bacteriostatic or antibacterial agent which comprises, as an active ingredient, a compound in which amino acid is bonded to cyclohexane carboxylic acid by means of an amide linkage and a salt thereof, with the compound represented by formula (1) where R represents neutral or acidic amino acid side chain. COPYRIGHT: (C)2015,JPOandINPIT
Monoenomycin: A simplified trienomycin A analogue that manifests anticancer activity
Brandt, Gary E. L.,Blagg, Brian S. J.
supporting information; experimental part, p. 735 - 740 (2011/12/02)
Macrocyclic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's "rule of 5", these compounds often demonstrate superior druglike physicochemical and pharmacokinetic attributes when compared to their acyclic counterparts. However, the elaborate structural architectures of such molecules require rigorous synthetic investigation that complicates analogue development and their application to drug discovery programs. To circumvent these limitations, a conformation-based approach using limited structure-activity relationships and molecular modeling was implemented to design simplified analogues of trienomycin A, in which the corresponding analogues could be prepared in a succinct manner to rapidly identify essential structural components necessary for biological activity. Trienomycin A is a member of the ansamycin family of natural products that possesses potent anticancer activity. These studies revealed a novel trienomycin A analogue, monoenomycin, which manifests potent anticancer activity.