244122-78-9

Basic information

• Product Name: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-methyl-1H-indole
• CAS NO: 244122-78-9
• Molecular Weight: 362.428
• Mol File: 244122-78-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-methyl-1H-indole(244122-78-9)
• EPA Substance Registry System: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-methyl-1H-indole(244122-78-9)

Safety Data

• Hazardous Substances Data: 244122-78-9(Hazardous Substances Data)

Upstream product

• 614-96-0 5-methyl-1H-indole 
• 61350-62-7 N-benzyloxycarbonyl-D-proline acid chloride 

Relevant articles and documents

5-Alkyltryptamine derivatives as highly selective and potent 5-HT(1D) receptor agonists

A series of 5-alkyltryptamines (6) and the corresponding conformationally constrained analogues (8) have been synthesized. The structure-activity relationships (SAR) at the 5-position of the indole skeleton and the ethylamine side chain have been studied.

5-ALKYL INDOLE COMPOUNDS

Described herein are compounds selective for the 5-HT 1D-like receptor, which have the general formula: STR1 wherein: R 1 is linear or branched loweralkyl;R 2 is selected from a group of Formula II, III, IV and V: STR2 R 3 is selected from H and loweralkyl; R 4 is selected from H and loweralkyl; One of R. sup. 5 and R 6 is H and the other is independently selected from H, loweralkoxy, loweralkyl and hydroxy; andn is 1-3; or a salt, solvate or hydrate thereof.Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of the 5-HT 1D-like receptor is implicated, such as migraine.