244221-57-6 Usage
Description
5-CHLORO-2-IODOPYRIDINE is an organic compound with the molecular formula C5H3ClIN2. It is a heterocyclic compound featuring a pyridine ring with a chlorine atom at the 5th position and an iodine atom at the 2nd position. 5-CHLORO-2-IODOPYRIDINE is known for its potential applications in various chemical and pharmaceutical processes due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
5-CHLORO-2-IODOPYRIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-CHLORO-2-IODOPYRIDINE is used as a starting material for the preparation of indolizines through a tandem palladium-catalyzed cross-coupling reaction and cycloisomerization. This process allows for the efficient synthesis of indolizines, which are important structural motifs in various biologically active compounds.
Used in Medicinal Chemistry:
5-CHLORO-2-IODOPYRIDINE is also utilized in the synthesis and structure-activity relationships of 2-aminoquinazoline derivatives. These derivatives have been identified as a novel class of metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators. mGlu5 is a target for various therapeutic applications, including the treatment of neurological disorders and cognitive impairments. The development of selective and potent mGlu5 negative allosteric modulators can lead to new therapeutic options for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 244221-57-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,4,2,2 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 244221-57:
(8*2)+(7*4)+(6*4)+(5*2)+(4*2)+(3*1)+(2*5)+(1*7)=106
106 % 10 = 6
So 244221-57-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H3ClIN/c6-5-2-1-4(7)3-8-5/h1-3H
244221-57-6Relevant articles and documents
A New, Simple, and General Synthesis of N -Oxides of Iodopyridines and Iodoquinolines via the Diazotization-Iodination of Heterocyclic Amino N -Oxides in the Presence of p -Toluenesulfonic Acid in Water
Krasnokutskaya, Elena A.,Chudinov, Alexey A.,Filimonov, Victor D.
, p. 1368 - 1372 (2017/12/26)
The diazotization of a series of N -oxides of aminopyridines and aminoquinolines under the action of sodium nitrite in the presence of KI and p -TsOH in water at room temperature leads to the formation of the corresponding N -oxides of iodopyridines and iodoquinolines in high yields. The method has a general character and can be used for the preparation of 3-, 2-, and 4- N -oxides of iodopyridines.
One-pot iodination of hydroxypyridines
Maloney, Kevin M.,Nwakpuda, Emily,Kuethe, Jeffrey T.,Yin, Jingjun
supporting information; experimental part, p. 5111 - 5114 (2009/10/24)
(Chemical Equation Presented) A one-pot, high-yielding iodination of hydroxypyridines and hydroxyquinolines is described. The iodination proceeds under mild conditions, and the products are obtained in high yield without the need for chromatographic purif
PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS
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Page/Page column 91, (2010/11/25)
The present invention relates to a class of compounds of general formula (I) and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R6, R7 and R10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.