89809-64-3

Basic information

• Product Name: 5-Chloro-2-cyanopyridine
• Synonyms: 2-PYRIDINECARBONITRILE, 5-CHLORO-;5-CHLORO-2-CYANOPYRIDINE;6-CYANO-3-CHLOROPYRIDINE;3-Chloro-6-cyanopyridine;5-CHLOROPYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile,5-chloro-(9CI);5-Chloro-2-cyanopyridine94%;5-Bromo-1,3-dimethyl-1H-pyrazole ,97%
• CAS NO: 89809-64-3
• Molecular Formula: C₆H₃ClN₂
• Molecular Weight: 138.55
• EINECS: -0
• Product Categories: NITRILE;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridines;Pyridine;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
• Mol File: 89809-64-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 106-108℃
• Boiling Point: 110°C/3mmHg(lit.)
• Flash Point: 98.5 °C
• Appearance: Light yellow cryst.
• Density: 1.33 g/cm³
• Vapor Pressure: 0.0403mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Methanol
• PKA: -2.60±0.10(Predicted)
• CAS DataBase Reference: 5-Chloro-2-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-cyanopyridine(89809-64-3)
• EPA Substance Registry System: 5-Chloro-2-cyanopyridine(89809-64-3)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3439 6.1/PG III
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 89809-64-3(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

6-Cyano-3-chloropyridine (cas# 89809-64-3) is a compound useful in organic synthesis.

InChI:InChI=1/C6H3ClN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H

Upstream product

• 460-19-5 ethanedinitrile 
• 126-99-8 chloroprene 
• 616-47-7 1-methyl-1H-imidazole 
• 67-66-3 chloroform 
• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 1851-22-5 3-chloropyridine-N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 544-92-3 copper(I) cyanide 
• 244221-57-6 5-chloro-2-iodo-pyridine 
• 16110-09-1 2,5 dichloropyridine 
• 557-21-1 dicyanozinc 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 626-60-8 3-Chloropyridine 
• 31181-89-2 5-chloro-2-pyridine carboxaldehyde 

Downstream Products

• 327056-55-3 5-chloro-N'-hydroxypyridine-2-carboximidamide 
• 943621-63-4 2-(5-chloropyridine-2-yl)-1H-imidazoline 
• 94952-46-2 1-(5-chloropyridin-2-yl)ethan-1-one 
• 327056-62-2 5-fluoropicolinonitrile 
• 871020-42-7 5-(4-amino-2-methylphenoxy)pyridine-2-carbonitrile 
• 67938-76-5 (5-chloropyridin-2-yl)methanamine 
• 132308-19-1 methyl 5-chloropyridine-2-carboxylate 
• 188918-74-3 5-cyclopropylpyridine-2-carbonitrile 
• 1086107-46-1 (S)-5-(2-(1-cyclohexylethylamino)benzo[d]thiazol-6-yloxy)picolinonitrile 
• 1211973-83-9 C₁₁H₁₂N₄O₃S 
• 1255650-79-3 6-cyano-N-(piperidine-1-carbonyl)nicotinamide 
• 1257310-80-7 (6-cyanopyridin-3-yl)-carbamic acid 2-trimethylsilanylethyl ester 
• 939039-26-6 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine 
• 939039-44-8 (5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methanimine 

Relevant articles and documents

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2

A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.

HYDRAZONE COMPOUNDS AND THEIR USE

The present invention relates to hydrazone compounds of Formula I: (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I as inhibitors of TRPM5 protein.

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.