24715-90-0

Basic information

• Product Name: 4-PYRROLIDINOBUTYLAMINE
• Synonyms: 4-PyrrolidinbutylaMine;(4-pyrrolidin-1-ylbutyl)amine;4-1-pyrrolidinylbutan-1-amine;4-pyrrolidin-1-ylbutylamine;4-Pyrrolidin-1-yl-butylamine;1-Pyrrolidinebutanamine;TIMTEC-BB SBB010289;RARECHEM AL BW 0242
• CAS NO: 24715-90-0
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;pyrrole
• Mol File: 24715-90-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 97°C 15mm
• Flash Point: 79.4 °C
• Appearance: /
• Density: 0.923 g/cm³
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.48±0.20(Predicted)
• Water Solubility: Soluble in water
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-PYRROLIDINOBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRROLIDINOBUTYLAMINE(24715-90-0)
• EPA Substance Registry System: 4-PYRROLIDINOBUTYLAMINE(24715-90-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 24715-90-0(Hazardous Substances Data)

Usage

Description

4-PYRROLIDINOBUTYLAMINE, also known as 4-(1-Pyrrolidinyl)-1-butanamine, is an organic compound with the molecular formula C9H20N2. It is a colorless to pale yellow liquid with a characteristic amine-like odor. 4-PYRROLIDINOBUTYLAMINE is known for its reactivity and is commonly used as a building block in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
4-PYRROLIDINOBUTYLAMINE is used as a reagent for the preparation of imidazolidinedione derivatives, which are known for their antimalarial properties. These derivatives are effective against various strains of Plasmodium, the parasite responsible for malaria, making this compound a valuable asset in the development of new antimalarial drugs.
Used in Organic Synthesis:
4-PYRROLIDINOBUTYLAMINE is also used as a building block in organic synthesis, allowing chemists to create a wide range of complex molecules with diverse applications. Its unique structure and reactivity make it a versatile component in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 3038, 1973 DOI: 10.1021/ja00790a064

InChI:InChI=1/C8H18N2/c9-5-1-2-6-10-7-3-4-8-10/h1-9H2

Upstream product

• 110-63-4 Butane-1,4-diol 
• 109-99-9 tetrahydrofuran 
• 7664-41-7 ammonia 
• 123-75-1 pyrrolidine 

Downstream Products

• 101872-91-7 3,4,5-trimethoxy-benzoic acid-(4-pyrrolidino-butylamide) 
• 102314-72-7 3,4,5-trimethoxy-trans-cinnamic acid-(4-pyrrolidino-butylamide) 
• 110045-54-0 N-(4-Chloro-phenyl)-N'-[4-(4-pyrrolidin-1-yl-butylamino)-6-trichloromethyl-[1,3,5]triazin-2-yl]-guanidine 
• 144154-98-3 7-Chloro-10-hydroxy-1-[(E)-4-pyrrolidin-1-yl-butylimino]-3-(3-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 64058-09-9 3-methyl-3-[4-(1-methyl-pyrrolidinium-1-yl)-butyl]-3-azonia-bicyclo[3.3.1]nonane; diiodide 
• 252003-32-0 3-(2,5-difluoro-4-methyl-benzyloxy)-5-[3-(4-pyrrolidin-1-yl butyl)-ureido]-isothiazole-4-carboxylic acid amide 
• 252003-65-9 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide 
• 401817-09-2 N-{4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}-N-(4-pyrrolidin-1-ylbutyl)amine 
• 441295-44-9 4-[[[3-(1-pyrrolidinyl)propyl]amino]methyl]benzonitrile 
• 441295-48-3 4-[[[4-(1-pyrrolidinyl)butyl]amino]methyl]benzonitrile 
• 945104-09-6 1-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)-3-(4-pyrrolidin-1-ylbutyl)urea 
• 1197879-81-4 4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-N-(4-pyrrolidin-1-yl-butyl)-benzamide 
• 505059-75-6 3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-N-[4-(pyrrolidin-1-yl)butyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine 

Relevant articles and documents

Steric effects in the catalytic amination of γ-, δ-, and ε-glycols

The amination of butane-1,4-diol, isomeric dipropylene glycols, and cyclohexane-1,4-diyldimethanol in the presence of nickel/copper/chromium catalysts has been studied. The effect of the initial glycol structure on the reaction selectivity has been estima