252003-65-9

Basic information

• Product Name: CP-547632
• Synonyms: CP-547632;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;4-Isothiazolecarboxamide, 3-((4-bromo-2,6-difluorophenyl)methoxy)-5-((((4-(1-pyrrolidinyl)butyl)amino)carbonyl)amino)-;CP-547632(CP 547632);3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox
• CAS NO: 252003-65-9
• Molecular Formula: C₂₀H₂₄BrF₂N₅O₃S
• Molecular Weight: 532.408
• EINECS: 200-258-5
• Mol File: 252003-65-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 548.601 °C at 760 mmHg
• Flash Point: 285.584 °C
• Appearance: /
• Density: 1.532
• Storage Temp.: 2-8°C
• PKA: 12.50±0.70(Predicted)
• CAS DataBase Reference: CP-547632(CAS DataBase Reference)
• NIST Chemistry Reference: CP-547632(252003-65-9)
• EPA Substance Registry System: CP-547632(252003-65-9)

Safety Data

• Hazardous Substances Data: 252003-65-9(Hazardous Substances Data)

Usage

Description

CP-547632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF). It selectively targets VEGFR2 and bFGF over other related tyrosine kinases, such as EGFR and PDGF receptor β (PDGFRβ), and effectively inhibits VEGFR2 autophosphorylation induced by VEGF in various cell models. CP-547632 also demonstrates the ability to decrease angiogenesis induced by VEGF or bFGF and suppress tumor growth in athymic mice.

Uses

Used in Pharmaceutical Industry:
CP-547632 is used as an anti-cancer agent for its ability to inhibit the growth of solid tumors by targeting VEGFR2 and bFGF, which play crucial roles in angiogenesis and tumor progression.
Used in Drug Development:
CP-547632 is used as a lead compound in the development of novel therapeutics for cancer treatment, particularly for targeting receptor tyrosine kinases involved in tumor growth and angiogenesis.
Used in Research Applications:
CP-547632 serves as a valuable research tool for studying the role of VEGFR2 and bFGF in various cellular processes, including cell proliferation, migration, and angiogenesis, as well as for investigating the mechanisms of action of potential anti-cancer drugs.

Upstream product

• 24715-90-0 4-Pyrrolidino-butylamin 

Downstream Products

• 252003-71-7 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide hydrochloride 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES

Processes and intermediates for the preparation of compounds of the Formula (1) and the pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, wherein R1, R2, and R3 have the definitions provided herei

Isothiazole derivatives useful as anticancer agents

The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2and R3are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods treating hyperproliferative disorders in mammals by administering the above compounds.