25093-89-4

Basic information

• Product Name: 2-chloro-2-(methanesulfonyl)-1-phenylethanone
• Synonyms: 2-chloro-2-(methanesulfonyl)-1-phenylethanone
• CAS NO: 25093-89-4
• Molecular Weight: 232.688
• Mol File: 25093-89-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-chloro-2-(methanesulfonyl)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-2-(methanesulfonyl)-1-phenylethanone(25093-89-4)
• EPA Substance Registry System: 2-chloro-2-(methanesulfonyl)-1-phenylethanone(25093-89-4)

Safety Data

• Hazardous Substances Data: 25093-89-4(Hazardous Substances Data)

Upstream product

• 38488-23-2 2-diazo-2-(methylsulfonyl)-1-phenylethan-1-one 
• 70-11-1 α-bromoacetophenone 
• 93-89-0 benzoic acid ethyl ester 
• 53066-72-1 2-bromo-2-methylsulfonyl-1-phenylethanone 
• 3708-04-1 2-methylsulfonyl-1-phenylethanone 
• 532-27-4 1-chloroacetophenone 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 90476-22-5 2,2-dichloro-2-methylsulfonyl-1-phenylethanone 
• 925901-27-5 2-bromo-2-chloro-2-methanesulfonyl-1-phenyl-ethanone 
• 2351-74-8 chloromethylsulfonylmethane 
• 65-85-0 benzoic acid 
• 3708-04-1 2-methylsulfonyl-1-phenylethanone 
• 93-89-0 benzoic acid ethyl ester 
• 84543-53-3 2-Ethylsulfanyl-2-methanesulfonyl-1-phenyl-ethanone 
• 25095-15-2 2-Chlor-2-methylsulfon-1-phenyl-ethanol-⁽¹⁾ 

Relevant articles and documents

Copper Triflate Mediated α-Monohalogenation of α-Diazo β-Ketosulfones with Ammonium Halides

Copper triflate mediated α-monohalogenation of α-diazo β-ketosulfones with ammonium halides provides the corresponding α-halo β-ketosulfones. Different metal triflates are investigated for this facile and efficient transformation. A plausible mechanism is proposed.

THE PREPARATION, SPECTRAL PROPERTIES, STRUCTURES, AND BASE-INDUCED CLEAVAGE REACTIONS OF SOME α-HALO-β-KETOSULFONES

The halogenation of β-ketosulfones such as α-methylsulfonylacetophenone (1) and benzenesulfonylacetone (10) can be effected with sulfuryl chloride or pyridinium bromide perbromide.Regiochemical control can be achieved by control of stoichiometry and/or the reaction conditions.Detailed 1H and 13C nmr, and mass spectra are recorded for a series of halogenated β-ketosulfones, together with structures by X-ray crystallography for 1, 2-chloro-2-methylsulfonyl-1-phenylethanone (2), chloromethyl methyl sulfone (4), and α-chloroacetophenone (21).Results from these studies are used to suggest a reason for the difficulty associated with substitution reactions of α-halosulfones.