252357-49-6

Basic information

• Product Name: ((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butyl)-carbamic acid benzyl ester
• Synonyms: ((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butyl)-carbamic acid benzyl ester
• CAS NO: 252357-49-6
• Molecular Weight: 782.867
• Mol File: 252357-49-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butyl)-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butyl)-carbamic acid benzyl ester(252357-49-6)
• EPA Substance Registry System: ((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butyl)-carbamic acid benzyl ester(252357-49-6)

Safety Data

• Hazardous Substances Data: 252357-49-6(Hazardous Substances Data)

Upstream product

• 38972-95-1 N-Benzyloxycarbonyl-L-isoleucyl-L-leucin 
• 252357-46-3 (R,S)-4-amino-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile 
• 252357-48-5 (+/-)-4-(N-benzyloxycarbonyl-amino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile 
• 16640-68-9 cyanomethylene triphenylphosphorane 

Downstream Products

• 438202-56-3 (2S,3S)-2-Amino-3-methyl-pentanoic acid {(S)-1-[3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butyl}-amide 
• 438202-62-1 4-((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butylcarbamoyloxymethyl)-benzoic acid methyl ester 
• 438202-43-8 4-{(1S,2S)-1-[(S)-1-((S)-3,3-Difluoro-1-oxalyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyloxymethyl}-benzoic acid methyl ester 

Relevant articles and documents

Evolution, synthesis and SAR of tripeptide α-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease

N-Terminal truncation of the hexapeptide ketoacid 1 gave rise to potent tripeptide inhibitors of the hepatitis C virus NS3 protease/NS4A cofactor complex. Optimization of these tripeptides led to ketoacid 30 with an IC50 of 0.38 μM. The SAR of these tripeptides is discussed in the light of the recently published crystal structures of a ternary tripetide/NS3/NS4A complexes.