38972-95-1 Usage
General Description
Z-ILE-LEU-OH is a chemical compound also known as N-Benzyloxycarbonyl-Isoleucyl-Leucine. It is a protease inhibitor that is commonly used in biochemical research and drug development. Z-ILE-LEU-OH is a synthetic inhibitor of the enzyme cathepsin K, a lysosomal cysteine protease that plays a key role in bone metabolism. Z-ILE-LEU-OH has been studied for its potential therapeutic applications in bone-related diseases such as osteoporosis and osteoarthritis. It works by blocking the activity of cathepsin K, which in turn inhibits bone resorption and can help to maintain bone density. Overall, Z-ILE-LEU-OH is an important chemical compound with potential applications in the treatment and prevention of bone disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 38972-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,9,7 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 38972-95:
(7*3)+(6*8)+(5*9)+(4*7)+(3*2)+(2*9)+(1*5)=171
171 % 10 = 1
So 38972-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H30N2O5/c1-5-14(4)17(18(23)21-16(19(24)25)11-13(2)3)22-20(26)27-12-15-9-7-6-8-10-15/h6-10,13-14,16-17H,5,11-12H2,1-4H3,(H,21,23)(H,22,26)(H,24,25)
38972-95-1Relevant articles and documents
Glycopeptide Synthesis: Selective C-terminal Deblocking and Peptide Chain Elongation of Glucosylserine Derivatives
Buchholz, Michael,Kunz, Horst
, p. 1859 - 1885 (2007/10/02)
Benzyloxycarbonyl-(Z-)serine 2-bromoethyl ester (3b) reacts with 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranosyl bromide (14) to give the glucosylserine ester 15.After conversion into the corresponding 2-iodoethyl ester 23 the carboxylic group is deblocked selectively by reductive elimination using zinc.In this procedure the Z and the carbohydrate protective functions as well as the sensitive O-glycoside bond remain unaffected.The glycosylserine 24 is condensed with amino acid 2-bromoethyl esters 2 to form protected glycodipeptide 2-bromoethyl esters 18 which are extended to give glycotripeptide esters 25 after selective carboxyl deblocking.Whereas protected serine dipeptides 5 are glycosylated with 14 to form the conjugates 18, the glycosylation of the serine tripeptides 10 was not successful.
