88962-32-7

Basic information

• Product Name: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-bromoethyl ester
• CAS NO: 88962-32-7
• Molecular Formula: C22H33BrN2O5
• Molecular Weight: 485.418
• Mol File: 88962-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-bromoethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-bromoethyl ester(88962-32-7)
• EPA Substance Registry System: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-bromoethyl ester(88962-32-7)

Safety Data

• Hazardous Substances Data: 88962-32-7(Hazardous Substances Data)

Upstream product

• 61-90-5 L-leucine 
• 3160-59-6 N-Cbz-L-Isoleucine 
• 88962-23-6 Leucin-2-bromethylester-hydrochlorid 

Downstream Products

• 88962-43-0 N-Benzyloxycarbonyl-L-isoleucyl-L-leucin-2-iodethylester 
• 38972-95-1 N-Benzyloxycarbonyl-L-isoleucyl-L-leucin 

Relevant articles and documents

Glycopeptide Synthesis: Selective C-terminal Deblocking and Peptide Chain Elongation of Glucosylserine Derivatives

Benzyloxycarbonyl-(Z-)serine 2-bromoethyl ester (3b) reacts with 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranosyl bromide (14) to give the glucosylserine ester 15.After conversion into the corresponding 2-iodoethyl ester 23 the carboxylic group is deblocked selectively by reductive elimination using zinc.In this procedure the Z and the carbohydrate protective functions as well as the sensitive O-glycoside bond remain unaffected.The glycosylserine 24 is condensed with amino acid 2-bromoethyl esters 2 to form protected glycodipeptide 2-bromoethyl esters 18 which are extended to give glycotripeptide esters 25 after selective carboxyl deblocking.Whereas protected serine dipeptides 5 are glycosylated with 14 to form the conjugates 18, the glycosylation of the serine tripeptides 10 was not successful.