254892-87-0

Basic information

• Product Name: 3-(4-bromophenyl)-2,2-dichlorocyclobutanone
• Synonyms: 3-(4-bromophenyl)-2,2-dichlorocyclobutanone
• CAS NO: 254892-87-0
• Molecular Weight: 293.975
• Mol File: 254892-87-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 3-(4-bromophenyl)-2,2-dichlorocyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)-2,2-dichlorocyclobutanone(254892-87-0)
• EPA Substance Registry System: 3-(4-bromophenyl)-2,2-dichlorocyclobutanone(254892-87-0)

Safety Data

• Hazardous Substances Data: 254892-87-0(Hazardous Substances Data)

Usage

Properties

highly reactive, potentially toxic

Uses

organic synthesis, precursor in chemical production

Structure

contains a cyclobutanone ring with two chlorine atoms and a bromophenyl group

Common applications

building block in pharmaceuticals, agrochemicals, fine chemicals

Importance of caution

reactivity and potential toxicity require careful handling in laboratory and industrial settings.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 254892-91-6 3-(4-bromophenyl)cyclobutanone 
• 29924-39-8 β-(4-bromophenyl)-γ-butyrolactone 
• 1033082-32-4 (-)-(R)-4-(4-bromophenyl)dihydrofuran-2(3H)-one 
• 1183047-51-9 3-(4-bromophenyl)cyclobutanol 
• 1236357-60-0 1-bromo-4-(3,3-difluorocyclobutyl)benzene 
• 254893-07-7 C₁₂H₁₃BN₂O₄ 
• 254892-99-4 3-(4-boronophenyl)cyclobutanone ethylene ketal 
• 254893-03-3 3-(4-boronophenyl)cyclobutanone 
• 254892-95-0 3-(4-bromophenyl)cyclobutanone ethylene ketal 
• 254892-82-5 1-amino-3-(4-dihydroxyborylphenyl)cyclobutanecarboxylic acid 

Relevant articles and documents

Copper-Catalyzed Sulfonylation of Cyclobutanone Oxime Esters with Sulfonyl Hydrazides

A copper-catalyzed radical cross-coupling of cyclobutanone oxime esters with sulfonyl hydrazides has been developed. The copper-based catalytic system proved crucial for cleavage of the C-C bond of cyclobutanone oximes and for selective C-S bond-formation involving persistent sulfonyl-metal radical intermediates. This protocol is distinguished by the low-cost catalytic system, which does not require ligand, base, or toxic cyanide salt, and by the use of readily accessible starting materials, as well as broad substrate scope, providing an efficient approach to various diversely substituted cyano-containing sulfones.

Metal-free chalcogenation of cycloketone oxime esters with dichalcogenides

We report the metal-free chalcogenation of cycloketone oxime esters with dichalcogenides via a radical process. Because of the metal-free condition and use of readily accessible dichalcogenides, this method is an effective and green strategy for the synthesis of chalcogen-substituted butyronitrile.

Metal-Free sp3 C-SCF3 Coupling Reactions between Cycloketone Oxime Esters and S-trifluoromethyl 4-Methylbenzenesulfonothioate

A novel sp3 C-SCF3 coupling reaction between cycloketone oxime esters and S-trifluoromethyl 4-methylbenzenesulfonothioate was achieved. Ethanol was found to facilitate this transformation by trapping the sulfonyl cation. The metal-free and photocatalyst-free reaction conditions, as well as the broad substrate scope, make this a green protocol for the synthesis of SCF3-substituted nitriles.