254892-91-6

Basic information

• Product Name: 3-(4-bromophenyl)cyclobutanone
• Synonyms: 3-(4-bromophenyl)cyclobutanone;Cyclobutanone, 3-(4-bromophenyl)-
• CAS NO: 254892-91-6
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225
• Mol File: 254892-91-6.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-bromophenyl)cyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)cyclobutanone(254892-91-6)
• EPA Substance Registry System: 3-(4-bromophenyl)cyclobutanone(254892-91-6)

Safety Data

• Hazardous Substances Data: 254892-91-6(Hazardous Substances Data)

Usage

Description

3-(4-bromophenyl)cyclobutanone is an organic compound characterized by its cyclobutanone core with a bromophenyl group attached at the 3-position. This molecule is known for its unique structural properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
3-(4-bromophenyl)cyclobutanone is used as a key intermediate in the synthesis of selective T-type calcium channel blockers. These blockers play a crucial role in the treatment of various cardiovascular and neurological disorders by modulating the flow of calcium ions through T-type calcium channels, which are essential for the proper functioning of the heart and nervous system.

Upstream product

• 254892-87-0 3-(4-bromophenyl)-2,2-dichlorocyclobutan-1-one 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 127-19-5 N,N-dimethyl acetamide 
• 463-51-4 Ketene 
• 1122-91-4 4-bromo-benzaldehyde 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 254892-95-0 3-(4-bromophenyl)cyclobutanone ethylene ketal 
• 254892-82-5 1-amino-3-(4-dihydroxyborylphenyl)cyclobutanecarboxylic acid 
• 254893-03-3 3-(4-boronophenyl)cyclobutanone 
• 254892-99-4 3-(4-boronophenyl)cyclobutanone ethylene ketal 
• 254893-07-7 C₁₂H₁₃BN₂O₄ 
• 1033082-32-4 (-)-(R)-4-(4-bromophenyl)dihydrofuran-2(3H)-one 
• 1019842-34-2 1-(1-benzyloxy-propa-1,2-dienyl)-3-(4-bromo-phenyl)-cyclobutanol 
• 1183047-51-9 3-(4-bromophenyl)cyclobutanol 
• 1236357-60-0 1-bromo-4-(3,3-difluorocyclobutyl)benzene 
• 1245831-62-2 3-(4-bromophenyl)-1-cyclopropylcyclobutanol 
• 1329607-69-3 C₁₆H₁₇BrO₂ 
• 1329607-70-6 C₁₆H₁₇BrO₂ 

Relevant articles and documents

Copper-Catalyzed Sulfonylation of Cyclobutanone Oxime Esters with Sulfonyl Hydrazides

A copper-catalyzed radical cross-coupling of cyclobutanone oxime esters with sulfonyl hydrazides has been developed. The copper-based catalytic system proved crucial for cleavage of the C-C bond of cyclobutanone oximes and for selective C-S bond-formation involving persistent sulfonyl-metal radical intermediates. This protocol is distinguished by the low-cost catalytic system, which does not require ligand, base, or toxic cyanide salt, and by the use of readily accessible starting materials, as well as broad substrate scope, providing an efficient approach to various diversely substituted cyano-containing sulfones.

Metal-free chalcogenation of cycloketone oxime esters with dichalcogenides

We report the metal-free chalcogenation of cycloketone oxime esters with dichalcogenides via a radical process. Because of the metal-free condition and use of readily accessible dichalcogenides, this method is an effective and green strategy for the synthesis of chalcogen-substituted butyronitrile.

PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS

The present disclosure provides processes for preparing 1,2,3-triazole-4-carboxylic acid related compounds of formulae (I) and (II) via a Suzuki coupling reaction. The Suzuki coupling reaction is achieved by coupling a compound of formula (IV), a boron-containing derivative of 1,2,3-triazole-4-carboxylate, with a cycloalkyl phenyl halide or sulfonate of formula (V).