257875-30-2Relevant articles and documents
Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors
Tanaka, Masahiro,Sagawa, Shoichi,Hoshi, Jun-ichi,Shimoma, Fumito,Yasue, Katsutaka,Ubukata, Minoru,Ikemoto, Tomoyuki,Hase, Yasunori,Takahashi, Mitsuru,Sasase, Tomohiko,Ueda, Nobuhisa,Matsushita, Mutsuyoshi,Inaba, Takashi
, p. 5781 - 5794 (2007/10/03)
Conformationally restricted 3-anilino-4-(3-indolyl)maleimide derivatives were designed and synthesized aiming at discovery of novel protein kinase Cβ (PKCβ)-selective inhibitors possessing oral bioavailability. Among them, compounds having a fused five-me