25836-92-4

Basic information

• Product Name: N-<4-Phenoxy-butyl>-anilin
• Synonyms: N-<4-Phenoxy-butyl>-anilin
• CAS NO: 25836-92-4
• Molecular Weight: 241.333
• Mol File: 25836-92-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-<4-Phenoxy-butyl>-anilin(CAS DataBase Reference)
• NIST Chemistry Reference: N-<4-Phenoxy-butyl>-anilin(25836-92-4)
• EPA Substance Registry System: N-<4-Phenoxy-butyl>-anilin(25836-92-4)

Safety Data

• Hazardous Substances Data: 25836-92-4(Hazardous Substances Data)

Upstream product

• 300-57-2 allylbenzene 
• 2653-89-6 4-phenoxy-1-butene 
• 100-68-5 methyl-phenyl-thioether 
• 16728-66-8 4-phenoxybutylamine 
• 2651-46-9 (4-chlorobutoxy)benzene 
• 62-53-3 aniline 

Relevant articles and documents

Linear Hydroaminoalkylation Products from Alkyl-Substituted Alkenes

The regioselective conversion of alkyl-substituted alkenes into linear hydroaminoalkylation products represents a strongly desirable synthetic transformation. In particular, such conversions of N-methylamine derivatives are of great scientific interest, because they would give direct access to important amines with unbranched alkyl chains. Herein, we present a new one-pot procedure that includes an initial alkene hydroaminoalkylation with an α-silylated amine substrate and a subsequent protodesilylation reaction that delivers linear hydroaminoalkylation products with high selectivity from simple alkyl-substituted alkenes. For that purpose, new titanium catalysts have been developed, which are able to activate the α-C?H bond of more challenging α-silylated amine substrates. In addition, a direct relationship between the ligand structure of the new catalysts and the obtained regioselectivity is described.