26117-20-4

Basic information

• Product Name: CARBAMOYL-LEU-OH
• Synonyms: L-4-METHYL-2-UREIDOPENTANOIC ACID;CARBAMOYL-LEUCINE;CARBAMOYL-LEU-OH;CARBAMOYL-L-LEUCINE
• CAS NO: 26117-20-4
• Molecular Formula: C₇H₁₄N₂O₃
• Molecular Weight: 174.2
• Mol File: 26117-20-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.9 °C at 760 mmHg
• Flash Point: 148.5 °C
• Appearance: /
• Density: 1.168 g/cm³
• Storage Temp.: Store at RT.
• CAS DataBase Reference: CARBAMOYL-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: CARBAMOYL-LEU-OH(26117-20-4)
• EPA Substance Registry System: CARBAMOYL-LEU-OH(26117-20-4)

Safety Data

• Hazardous Substances Data: 26117-20-4(Hazardous Substances Data)

Usage

General Description

CARBAMOYL-LEU-OH is a chemical compound that is a derivative of carbamoyl-L-leucine. It is a synthetic form of the amino acid leucine, which plays a crucial role in protein synthesis and muscle maintenance. CARBAMOYL-LEU-OH is often used in biochemical research and as a building block for the synthesis of peptides. It has potential applications in pharmaceuticals and drug development due to its ability to mimic natural amino acids and interact with biological systems. Additionally, it may have potential as a dietary supplement to support muscle growth and overall health.

Upstream product

• 61-90-5 L-leucine 
• 372-75-8 Citrulline 
• 760-84-9 L-leucine hydrochloride 
• 58942-03-3 L-5-isobutylhydantoin 
• 40856-75-5 5-(2-methylpropyl)-2,4-imidazolidinedione 
• 590-28-3 potassium cyanate 
• 57-13-6 urea 

Downstream Products

• 61-90-5 L-leucine 
• 57-13-6 urea 
• 686-50-0 L-leucyl-glycine 
• 258830-48-7 (R)-4-[2-((S)-1-Carboxy-3-methyl-butyl)-2H-pyrazol-3-yl]-oxazolidine-3-carboxylic acid benzyl ester 
• 258830-60-3 (R)-4-[1-((S)-1-Carboxy-3-methyl-butyl)-1H-pyrazol-3-yl]-oxazolidine-3-carboxylic acid benzyl ester 
• 258833-81-7 (S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-4-methyl-pentanoic acid methyl ester 
• 258833-69-1 (S)-2-[5-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

Microwave-assisted synthesis of N-monosubstituted urea derivatives

An easy and rapid procedure for the preparation of N-monosubstituted ureas via reaction between potassium cyanate and a wide range of amines is described. The procedure was performed under microwave irradiation using water as solvent. This methodology is particularly attractive since it provides ureas in high yield and purity. Georg Thieme Verlag Stuttgart · New York.

A pH-dependent cyanate reactivity model: Application to preparative N-carbamoylation of amino acids

Recent developments in peptide synthesis have underlined the importance of optimising, on a preparative scale, the N-carbamoylation of amino acids by aqueous cyanate. To this purpose, a theoretical model of aqueous cyanate reactivity was designed. The parameters of the model were evaluated, for various pH and temperatures, from a critical survey of the literature, together with additional experimental data. Computer-simulated kinetics based on this model showed the reaction efficiency to be significantly dependent on pH, and suggested optimum conditions to be moderate temperatures and pH 8.5-9. Discussion of the practical convenience of these theoretical results led us to prefer 40-50 °C and a pH range of 7-8 as reaction conditions, thus maintaining reaction times within a few hours. Various N-carbamoyl amino acids (ureido derivatives of glycine, L-valine, L-alanine, L-leucine, DL-methionine, Nε-trifluoroacetyl-L-lysine, β-alanine) were thus successfully synthesised on the gram to kilogram scales.

Microbial conversion of DL-5-substituted hydantoins to the corresponding L-amino acids by Bacillus stearothermophilus NS1122A

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