264916-06-5

Basic information

• Product Name: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
• Synonyms: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE;5-Amino-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester;5-Amino-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester;5-Amino-2-(tert-butoxycarbonyl)isoindoline;5-Aminoisoindoline-2-carboxylic acid tert-butyl ester;tert-butyl 5-aMinoisoin;tert-butyl 5-aMino-2,3-dihydro-1H-isoindole-2-carboxylate
• CAS NO: 264916-06-5
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.29
• Mol File: 264916-06-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 376.304 °C at 760 mmHg
• Flash Point: 181.382 °C
• Appearance: /
• Density: 1.177
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.76±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE(264916-06-5)
• EPA Substance Registry System: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE(264916-06-5)

Safety Data

• Hazardous Substances Data: 264916-06-5(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE is a chemical compound with the molecular formula C15H18N2O2. It is a tert-butyl ester derivative of 5-aminoisatin, an intermediate in the synthesis of various pharmaceuticals. The compound has been studied for its potential biological activities, including its role as a potential anti-tumor agent and as a pharmacological chaperone for the treatment of lysosomal storage disorders. Additionally, it has been investigated for its potential use in the synthesis of novel heterocyclic compounds with biological activities. Overall, TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE shows promise as a versatile compound with various potential applications in medicinal chemistry and pharmaceutical research.

InChI:InChI=1/C13H18N2O2/c1-13(2,3)17-12(16)15-7-9-4-5-11(14)6-10(9)8-15/h4-6H,7-8,14H2,1-3H3

Upstream product

• 400727-63-1 tert-butyl 5-nitroisoindoline-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 46053-72-9 5-nitroisoindoline 
• 496-12-8 isoindoline 
• 832-51-9 1-(1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroethanone 
• 1059172-96-1 2,2,2-trifluoro-1-(5-nitroisoindolin-2-yl)ethan-1-one 

Downstream Products

• 784137-02-6 4-butyl-N-(2,3-dihydro-1H-isoindol-5-yl)-benzenesulfonamide 
• 945488-70-0 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-methoxyphenyl)-β-alanine 
• 945488-73-3 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopropoxyphenyl)-β-alanine 
• 945488-71-1 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-ethoxyphenyl)-β-alanine 
• 945488-77-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine 
• 945488-72-2 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-propoxyphenyl)-β-alanine 
• 945488-75-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isobutyloxyphenyl)-β-alanine 
• 945488-74-4 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-butoxyphenyl)-β-alanine 
• 945488-76-6 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopentyloxyphenyl)-β-alanine 
• 807627-84-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine methyl ester 
• 807627-86-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine 
• 264916-07-6 2-tert-butoxycarbonyl-5-(2-nitrophenylamino)isoindoline 
• 1036389-24-8 C₂₃H₂₈N₂O₆ 
• 1264924-32-4 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate 

Relevant articles and documents

THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF

The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.