807627-84-5Relevant articles and documents
Novel fibrinogen receptor antagonists. RGDF mimetics, derivatives of 4-(isoindoline-5-yl)amino-4-oxobutyric acid
Krysko, Andrei A.,Chugunov, Boris M.,Malovichko, Olga L.,Andronati, Sergei A.,Kabanova, Tatyana A.,Karaseva, Tamara L.,Kiriyak, Anna V.
, p. 5533 - 5535 (2004)
The novel RGDF mimetics 9a and 9b were synthesized with the use of 4-(isoindoline-5-yl)amino-4-oxobutyric acid as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to bloc