26537-19-9 Usage
Description
Methyl 4-tert-butylbenzoate is a white crystalline powder that is slightly soluble in water and miscible in various organic solvents such as ethanol, ether, and toluene. It serves as an important intermediate for organic synthesis and has a wide range of applications in different industries due to its unique chemical properties.
Uses
1. Used in Chemical Synthesis:
Methyl 4-tert-butylbenzoate is used as an important intermediate for organic synthesis, particularly in the synthesis of tris(4-tert-butylphenyl)methyl chloride and avobenzone, an ingredient in sunscreen products.
2. Used in Plastics Industry:
Methyl 4-tert-butylbenzoate is used as an additive in the production of PVC heat stabilizers and PP nucleating agents. It enhances the luster, color, and drying time of the resin, as well as improves its chemical resistance.
3. Used in Coatings Industry:
As an alkyd resin modifier, Methyl 4-tert-butylbenzoate improves the luster, color, and drying time of the resin, and enhances its chemical resistance.
4. Used in Lubricants and Cutting Oils:
The ammonium salt of Methyl 4-tert-butylbenzoate can improve the performance of friction parts and prevent rust, making it suitable for use as additives in cutting oils and lubricants.
5. Used in Polymer Stabilization:
The sodium, barium, and zinc salts of Methyl 4-tert-butylbenzoate can be used as polymer stabilizers and nucleating agents, contributing to the stability and performance of various polymers.
Synthesis method
The synthesis method of P-tert-butyl benzoic acid includes:
The oxidation method of liquid phase solvent, take acetic acid as solvent, lead acetate as oxidant and synthesize p-tert-butyl benzoic acid at low temperature.
Liquid non-solvent oxidation method: there is no need of any solvent; take cobalt acetate and sodium bromide as a catalyst and apply air oxidation at 170e temperature to obtain the final products.
High temperature gas phase oxidation method, in the presence of catalyst, high temperature lead to vaporization and oxidation of p-tert-butyl toluene to generate p-tert-butyl benzoic acid.
Recently, we found that there is no need of any catalyst if using cheap nitric acid as the oxidant for oxidation of p-tert-butyl toluene to get the crude t-butyl benzoic acid, followed by being dissolved with sodium hydroxide to remove organic impurities and insoluble matter, and then being acidified to obtain pure p-tert-butyl benzoic acid. This method has good selectivity and low energy consumption, and can avoid the shortcomings of air oxidation method such as low oxidation conversion rate, thus having great practical value.
Preparation of crude p-tert-butyl benzoic acid:
To a 500 mL autoclave, add 26 mL (0.2 mol, 29.6 g) of p-tert-butyltoluene, 26 mL 68% nitric acid (0.4 mol, 37 g) and 2.5 mL of water. The reaction stirrer was started and the temperature was raised to 180e. The reaction lasted for 8 hour followed by cooling with cool water. Open the reactor with most of the solid being deposited on the bottom of the reactor and attached to the reactor cooling tube in a small amount. The solid was collected, filtered and dried to give 34.5 g with a yield of 95.5%.
The purification of P-tert-butylbenzoic acid
Weigh 10 g of sodium hydroxide and add 90 mL of water to prepare a 10% sodium hydroxide solution. Add the above solid into it. After being sufficiently dissolved, the filtrate was adjusted to pH 3 with hydrochloric acid, and a large amount of crystals would be precipitated at this time. The solution was allowed to stand for 33.4 g with a yield of 98.2%. The product was analyzed by infrared spectroscopy, displaying the characteristic peaks of p-tert-butylbenzoic acid. The content was 98.4% by HPLC analysis with a melting point of 164~166e (literature values 164~165e).
The effect of nitric acid concentration, reaction temperature and reaction time on the synthesis of products
Effect of nitric acid concentration on the product
A series of nitric acid concentration experiments were carried out at two temperatures. The reaction temperature of curve 1 was 160e and the reaction temperature of curve 2 was 180e. The product content was obtained by liquid chromatography (HPLC) normalization. It can be seen that with the decrease of nitric acid concentration, the content of p-tert-butylbenzoic acid increased, the concentration of nitric acid decreased to about 10%. When the temperature reached 180e, the content reaches the highest value. When the concentration of nitric acid was higher than 50%, we couldn’t obtain the desired product. In addition, in this experiment, it could also be seen the impact of temperature on the product. The content in the series of high temperature was significantly higher than that of the low temperature series.
The effect of reaction temperature on the product
Considering the effect of reaction temperature, we selected the concentration of nitric acid at 10%. The effect of temperature on the product was that the reactant could not get the desired product at the reflux temperature. With the increase of temperature, the product content exhibits an increasing trend. At 170e, the content reaches the highest value with further increasing the temperature having almost no effect on the content.
The effect of reaction time on the reaction
A large number of experiments have found that the reaction time only affects the reaction conversion rate, without affecting product selectivity. That is, it does not affect the content of the product and only affects the yield of the product. In the experiment, it can be clearly seen of that the reaction time is not enough when the reactor floating above a layer of liquid organic matter, the analysis is the raw material of tert-butyl toluene.
From the analysis of the data, we can see that the reaction temperature has the greatest influence on the yield. Considering various factors, we selected the reaction conditions as: the temperature: 180e, reaction time: 8h and nitric acid concentration: 10%. According to this condition, the content of p-tert-butylbenzoic acid was 98.4% and the yield was 95.5%.
Synthesis Reference(s)
Tetrahedron, 42, p. 553, 1986 DOI: 10.1016/S0040-4020(01)87454-8
Check Digit Verification of cas no
The CAS Registry Mumber 26537-19-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,5,3 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 26537-19:
(7*2)+(6*6)+(5*5)+(4*3)+(3*7)+(2*1)+(1*9)=119
119 % 10 = 9
So 26537-19-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O2/c1-12(2,3)10-7-5-9(6-8-10)11(13)14-4/h5-8H,1-4H3
26537-19-9Relevant articles and documents
Dual Nickel/Photoredox-Catalyzed Deaminative Cross-Coupling of Sterically Hindered Primary Amines
Dorsheimer, Julia R.,Ashley, Melissa A.,Rovis, Tomislav
supporting information, p. 19294 - 19299 (2021/11/23)
We report a method to activate α-3° amines for deaminative arylation via condensation with an electron-rich aldehyde and merge this reactivity with nickel metallaphotoredox to generate benzylic quaternary centers, a common motif in pharmaceuticals and natural products. The reaction is accelerated by added ammonium salts. Evidence is provided in support of two roles for the additive: inhibition of nickel black formation and acceleration of the overall reaction rate. We demonstrate a robust scope of amine and haloarene coupling partners and show an expedited synthesis of ALK2 inhibitors.
Mild Copper-Catalyzed Addition of Arylboronic Esters to Di- tert -butyl Dicarbonate: An Easy Access to Methyl Arylcarboxylates
Xu, Jin-Di,Su, Xiao-Bo,Wang, Cai,Yao, Li-Wei,Liu, Jing-Hui,Hu, Guo-Qin
supporting information, p. 833 - 837 (2021/02/26)
An efficient copper-catalyzed addition of arylboronic esters to (Boc) 2O was developed. The reaction can be conducted under exceedingly mild conditions and is compatible with a variety of synthetically relevant functional groups. It therefore represents a useful alternative route for the synthesis of methyl arylcarboxylates. A preliminary mechanistic study indicated the involvement of an addition-elimination mechanism.
Activity of a New Chromium(III) Complex with a Pentadentate (N3O2) Schiff-Base Ligand in the Reaction of Carbon Dioxide with Propylene Oxide
Bazhenova, T. A.,Chukanova, O. M.,Kornev, A. B.,Manakin, Yu. V.,Sedov, I. V.,Sheverdenkina, O. G.,Yakushev, I. A.
, p. 428 - 435 (2021/06/14)
Abstract: The reaction of carbon dioxide with propylene oxide was carried out in the presence of a new pentadentate chromium complex, dichloro[2,6-diacetylpyridine bis(4-tert-butylbenzoylhydrazone)]chromium(III). The reaction kinetics was studied under different reaction conditions (temperature, pressure, and catalyst concentration). Optimal conditions for the synthesis of cyclic carbonate in the presence of the new chromium complex were found. The effective activation energy of the formation of cyclic carbonate was determined. The catalyst activity significantly depended on the substituent R in a 2,6-diacetylpyridine bis(4-R-benzoylhydrazone) ligand.
