2688-84-8Relevant articles and documents
Highly robust magnetically recoverable Ag/Fe2O3 nanocatalyst for chemoselective hydrogenation of nitroarenes in water
Patra, Astam K.,Vo, Nhat Tri,Kim, Dukjoon
, p. 148 - 156 (2017)
This work reports on additive-free Ag nanoparticles (4–6?nm) deposition on magnetic α-Fe2O3 nanocrystals surface by the slow reduction of AgNO3 with NaBH4 in aqueous medium. The EDS analysis revealed that the new materials contain 3.93?wt% of Ag nanoparticle on the surface of α-Fe2O3 which are the active suite for hydrogenation reaction. The Ag/Fe2O3 nanocatalysts exhibited good catalytic ability toward chemoselective hydrogenation of nitroarenes in water. LC–MS study suggested that the catalytic reaction pathway is –NO2, –NHOH, –NH2 and certainly skips the nitrosoarene intermediate step. The nanocatalysts are very efficient in the hydrogenation of nitroarenes tolerating –H, –Br, –I, –OH, –OCH3, –COOH and –CONH2 functional groups. The nanocatalysts were separated by external magnet and recycled in aqueous medium which offer environmentally and safe approach to this hydrogenation reaction. The catalyst was tested up to 10 recycles and showed no significant loss of catalytic activity.
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation
Su, Haixia,Zou, Yi,Chen, Guofeng,Dou, Huixia,Xie, Hang,Yuan, Xiaojing,Zhang, Xianglei,Zhang, Naixia,Li, Minjun,Xu, Yechun
, p. 4090 - 4106 (2020/05/20)
Fatty-acid binding protein 4 (FABP4) is a promising therapeutic target for immunometabolic diseases, while its potential for systemic inflammatory response syndrome treatment has not been explored. Here, a series of 2-(phenylamino)benzoic acids as novel and potent FABP4 inhibitors are rationally designed based on an interesting fragment that adopts multiple binding poses within FABP4. A fusion of these binding poses leads to the design of compound 3 with an ?460-fold improvement in binding affinity compared to the initial fragment. A subsequent structure-aided optimization upon 3 results in a promising lead (17) with the highest binding affinity among all the inhibitors, exerting a significant anti-inflammatory effect in cells and effectively attenuating a systemic inflammatory damage in mice. Our work therefore presents a good example of lead compound discovery derived from the multiple binding poses of a fragment and provides a candidate for development of drugs against inflammation-related diseases.
COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME
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, (2019/04/14)
Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): wherein Y is an oxygen atom or a sulfur atom; X1 and X2 are each independently C(Ra), the two (Ra)s are the same or different, and the two (Ra)s are joined together to form a first aryl ring; X3 and X4 are each independently C(Rb), the two (Rb)s are the same or different, and the two (Rb)s are joined to form a second aryl ring or a heteroaryl ring.