2741-16-4Relevant articles and documents
Houser et al.
, p. 1387,1388 (1974)
Radical Anion Promoted Chemoselective Cleavage of Csp2-S Bond Enables Formal Cross-Coupling of Aryl Methyl Sulfones with Alcohols
Bai, Jixiang,Wang, Tianxin,Dai, Botao,Liu, Qingchao,Yu, Peiyuan,Jia, Tiezheng
supporting information, p. 5761 - 5765 (2021/08/16)
A novel formal cross-coupling of aryl methyl sulfones and alcohols affording alkyl aryl ethers via an SRN1 pathway is developed. Two marketed antitubercular drugs were efficiently prepared employing this approach as the key step. A dimsyl-anion initiated radical chain process was revealed as the major pathway. DFT calculations indicate that the formation of a radical anion via nucleophilic addition of alkoxide to the aryl radical is the key step in determining the observed chemoselectivity.
Synthesis and catalytic performance of HMCM-49/MCM-41 composite molecular sieve for alkylation of phenol with isopropanol
Wei, Liguo,Wang, Dong,Dong, Yongli,Song, Weina,Liu, Xiaoxu,Song, Kunyao
, p. 2061 - 2066 (2017/01/28)
HMCM-49/MCM-41 composite molecular sieve was synthesized with hydrothermal method. The physicochemical properties of the composite were characterized by using XRD, FT-IR, SEM, N2 isothermal adsorption-desorption and NH3-TPD. Results of different characterizations indicated that the synthesized composite molecular sieve possessed the characteristics of both HMCM-49 and MCM-41. XRD and N2 isothermal adsorption-desorption revealed that it has both micropores and mesopores, a larger surface area than that of HMCM-49, NH3-TPD and pyridine adsorbed FT-IR revealed that the strong acidic sites that caused side reaction in HMCM-49 are deactivated in the composite molecular sieve of HMCM-49/MCM-41. When applied to the alkylation of phenol with isopropanol, the HMCM-49/MCM-41 composite molecular sieve exhibit an enhanced catalytic performance with significant enhancement in p-isopropylphenol and o-isopropylphenol selectivity, which can be ascribed to the composite characteristics of HMCM-49 and MCM-41. This kind of material will has widely industrial application in preparation of alkyl-phenol.
