28177-48-2

Basic information

• Product Name: 2,6-Difluorophenol
• Synonyms: 2,6-DIFLUOROPHENOL;Phenol, 2,6-difluoro-;2,6-Difluorophenol 98%;2,6-Difluorophenol98%;2,6-DIFLUOROPHENOL: 96.5%
• CAS NO: 28177-48-2
• Molecular Formula: C₆H₄F₂O
• Molecular Weight: 130.09
• EINECS: 248-884-9
• Product Categories: Fluoro-Aromatics;Aromatic Phenols;Fluorobenzene;Phenol&Thiophenol&Mercaptan;Fluorophenols;Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 28177-48-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 38-41 °C(lit.)
• Boiling Point: 59-61 °C17 mm Hg(lit.)
• Flash Point: 138 °F
• Appearance: Colorless/Crystalline Low Melting Solid
• Density: 1,27 g/cm3
• Vapor Pressure: 2.11mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: 2-8°C
• Solubility: ethanol: soluble50mg/mL, clear, colorless to light yellow
• PKA: 7.45±0.10(Predicted)
• Water Solubility: Slightly soluble in water. Soluble in ethanol.
• BRN: 2043613
• CAS DataBase Reference: 2,6-Difluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorophenol(28177-48-2)
• EPA Substance Registry System: 2,6-Difluorophenol(28177-48-2)

Safety Data

• Hazard Codes: F,Xi,Xn
• Statements: 11-36/37/38-20/21/22
• Safety Statements: 26-36/37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 10
• HazardClass: 4.1
• PackingGroup: II
• Hazardous Substances Data: 28177-48-2(Hazardous Substances Data)

Usage

Description

2,6-Difluorophenol is a colorless crystalline low melting solid that is known for its unique chemical properties and versatile applications across various industries.

Uses

Used in Polymer Synthesis:
2,6-Difluorophenol is used as a monomer for the production of poly(2,6-difluoro-1,4-phenylene oxide) through oxidative polymerization. This process involves the use of the Fe-N,N'-bis(salicylidene)ethylenediamine (salen) complex as a catalyst and hydrogen peroxide as an oxidizing agent. The resulting polymer has potential applications in various fields due to its enhanced properties.
Used in Pharmaceutical Industry:
2,6-Difluorophenol is used as a pharmaceutical intermediate, playing a crucial role in the synthesis of various drugs and medications. Its unique chemical structure allows for the development of new compounds with potential therapeutic benefits.

InChI:InChI=1/C6H4F2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H

Upstream product

• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 372-18-9 1,3-Difluorobenzene 
• 162101-25-9 2,6-difluorophenylboronic acid 
• 820220-75-5 2,6-difluorophenyl phenyl sulfate 
• 437-81-0 2,6-difluorobenzaldehyde 
• 2040-90-6 2-chloro-6-fluorophenol 
• 1228447-86-6 (2,6-difluorophenyl)(isopropoxy)dimethylsilane 
• 688-71-1 tri-n-propyl borate 
• 108-95-2 phenol 
• 5509-65-9 2,6-difluoroaniline 
• 18063-03-1 2,6-difluorobenzamide 
• 121602-93-5 3,4,5-trifluorobenzoic acid 

Downstream Products

• 363-45-1 2,6-difluorophenoxyacetic acid 
• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 117923-74-7 C₆⁽¹³⁾CH₆F₂O 
• 118276-06-5 3,5-difluoro-4-hydroxybenzaldehyde 
• 2362-50-7 thianthrene-5-oxide 
• 139656-65-8 5-(4-hydroxy-3,5-di-fluorophenyl)thianthreniumyl perchlorate 
• 92-85-3 Thianthrene 
• 113981-42-3 sodium 2,6-difluorophenolate 
• 84959-65-9 2,6-difluorobenzene-1,4-diol 
• 151503-36-5 1-(2,6-Difluoro-phenoxymethyl)-2,3,4,5,6-pentafluoro-benzene 
• 36914-78-0 2',6'-difluorophenyl acetate 
• 658-07-1 2,6-Difluoro-4-nitrophenol 
• 141286-91-1 (2,6-difluorophenoxy)acetic acid methyl ester 
• 100-02-7 4-nitro-phenol 

Relevant articles and documents

Synthesis method of fluorine-containing phenol structure compound

The invention discloses a synthesis method of a fluorine-containing phenol structure compound, and belongs to the technical field of chemical synthesis. Fluorine-containing benzoic acid is subjected to a one-pot reaction in a solvent under the action of alkali to obtain fluorine-containing phenate, and fluorine-containing phenol is obtained after acid regulation and dissociation. The synthesis method has the advantages of rich, cheap and easily available raw material structure, short synthesis steps, mild reaction conditions, simple and convenient operation, high synthesis yield, good productquality, wide application range and the like, and is suitable for simple and efficient synthesis of various high-value and high-purity fluorine-containing phenol compounds.

A aqueous phase preparation 2, 6 - [...] method

The invention relates to a green preparation 2, 6 - [...] synthetic method, to industrial product is 2, 6 - difluoro-benzamide as the starting material, passes through the aqueous phase Huffman degradation reaction, the aqueous phase diazotisations directly after the hydrolysis, direct concentrated nitric acid nitration, the iron powder reduces the aqueous phase, the aqueous phase with the aqueous phase to diazotization coupling reaction of phenol, after five step process for preparing aqueous phase reactions 2, 6 - [...] production process and corresponding various process conditions. The beneficial effect of the present invention is: select industrialized product 2, 6 - difluoro-benzamide as the raw material, raw materials are easy, low cost, through the aqueous phase reaction and solvent-free reaction for the preparation of 2, 6 - [...], its mild reaction conditions and environmental, safety and high efficiency. The present invention provides a kind of environmental protection, model, high efficiency can be used for the industrial production of 2, 6 - [...] green synthetic pathway.

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.