437-82-1

Basic information

• Product Name: 2,6-Difluoroanisole
• Synonyms: 2,6-DIFLUOROANISOLE;2,6-Difluoroanisole, 97+%;2,6-Difluoroanisole 98%;2,6-Difluoroanisole98%;2,6-DIFLUOROANISOLE: 98.5%;1,3-difluoro-2-methoxybenzene
• CAS NO: 437-82-1
• Molecular Formula: C₇H₆F₂O
• Molecular Weight: 144.12
• Product Categories: Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 437-82-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 70-72°C 56mm
• Flash Point: 61°C
• Appearance: /
• Density: 1.221
• Vapor Pressure: 3.73mmHg at 25°C
• Refractive Index: 1.4570 to 1.4620
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,6-Difluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluoroanisole(437-82-1)
• EPA Substance Registry System: 2,6-Difluoroanisole(437-82-1)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 437-82-1(Hazardous Substances Data)

Usage

physical state

2,6-Difluoroanisole is a Liquid.

Uses

2,6-Difluoroanisole is an ether derivative and can be used as an organic reagent.

InChI:InChI=1/C7H6F2O/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3

Upstream product

• 437-83-2 3-fluoro-2-methoxyaniline 
• 186581-53-3 diazomethane 
• 28177-48-2 2,6-difluorophenol 
• 1489-53-8 1,2,3-trifluorobenzene 
• 484-94-6 1-fluoro-2-methoxy-3-nitrobenzene 
• 74-88-4 methyl iodide 
• 372-18-9 1,3-Difluorobenzene 
• 162101-25-9 2,6-difluorophenylboronic acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 28177-48-2 2,6-difluorophenol 
• 392-25-6 1,3-difluoro-2-methoxy-5-nitrobenzene 
• 1005402-90-3 4-(3,5-difluoro-4-methoxyphenyl)-4-oxo-butyric acid ethyl ester 
• 363-47-3 3,5-difluoro-4-methoxyaniline 
• 151414-41-4 N-(3,5-difluoro-4-hydroxyphenyl)acetamide 
• 151414-45-8 3,5-difluoro-4-methoxyacetanilide 
• 443-42-5 3,5-difluoro-4-methoxyphenol 
• 363-48-4 4-nitro-benzoic acid-(3,5-difluoro-4-methoxy-anilide) 
• 348-92-5 5-(2,6-diiodo-4-nitro-phenoxy)-1,3-difluoro-2-methoxy-benzene 
• 499-43-4 4,4'-dimethoxy-3,3',5,5'-tetrafluoroazoxybenzene 
• 400-84-0 4-(3,5-difluoro-4-methoxy-phenoxy)-3,5-diiodo-aniline; hydrochloride 
• 363-45-1 2,6-difluorophenoxyacetic acid 
• 718609-92-8 (2-Methoxy-3-fluoro-phenyl)-cyclopropyl-carbonitrile 
• 825654-68-0 2-(3-fluoro-2-methoxyphenyl)-2-methylpropannitrile 

Relevant articles and documents

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.

HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS

The invention relates to pentanol derivatives of general formula (I), which are substituted by quinazoline, quinoxaline, cinnoline, indazole, phthalazine, naphthyridine, benzothiazole, dihydroindolone, dihydroisoindolone, benzimidazole, or indole, a method for the production thereof, and the use thereof as anti-inflammatory agents.

Quinolonecarboxylic acid derivatives or salts thereof

PCT No. PCT/JP97/00317 Sec. 371 Date Aug. 10, 1998 Sec. 102(e) Date Aug. 10, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/29102 PCT Pub. Date Aug. 14, 1997The present invention relates to a quinolone-carboxylic acid derivative represented by the general