29113-65-3Relevant articles and documents
nBu4NI-catalyzed C–C bond formation to construct 2-carbonyl-1,4-diketones under mild conditions
Lv, Yunhe,Pu, Weiya,Niu, Jiejie,Wang, Qingqing,Chen, Qian
, p. 1497 - 1500 (2018)
An nBu4NI-catalyzed oxidative cross-dehydrogenative-coupling of β-dicarbonyl compounds with acetone under mild reaction conditions is described. This methodology provides a straightforward pathway to synthesize 2-carbonyl-1,4-diketones and feat
Synthesis of 3-Carbonyl Trisubstituted Furans via Pd-Catalyzed Aerobic Cycloisomerization Reaction: Development and Mechanistic Studies
Barboza, Amanda A.,Neto, Attilio Chiavegatti,Rosset, Isac G.,Jardim, Guilherme A. M.,Ferreira, Marco A. B.
, p. 3923 - 3942 (2021/04/02)
Herein, we report the synthesis of 3-carbonyl-trisubstituted furans via Pd-catalyzed oxidative cycloisomerization reactions of 2-alkenyl-1,3-dicarbonyl scaffolds, using molecular oxygen as the sole oxidant to regenerate active palladium catalytic species, featuring good functional tolerance and mild reaction conditions. Deep investigation of intermediates and transition states of the reaction mechanism were conducted via experimental and DFT studies, providing a detailed mechanistical profile. The new developed methodology presents a greener alternative to Wacker-type cycloisomerizations and avoids the use of stoichiometric amounts of oxidants and strong acid additives.
Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ
Lei, Jie,Xu, Zhi-Gang,Tang, Dian-Yong,Li, Yong,Xu, Jia,Li, Hong-Yu,Zhu, Jin,Chen, Zhong-Zhu
, p. 292 - 297 (2018/05/24)
Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.