64354-50-3

Basic information

• Product Name: 5-METHYL-2-PHENYL-3-FUROIC ACID
• Synonyms: RARECHEM AL BO 2096;5-METHYL-2-PHENYL-3-FUROIC ACID;CHEMBRDG-BB 5926078;5-Methyl-2-phenyl-3-furoic acid 97%;5-Methyl-2-phenyl-3-furancarboxylic acid;Phenuvic acid;5-methyl-2-phenyl-3-furoic acid(SALTDATA: FREE);5-Methyl-2-phenyl-3-furoicacid97%
• CAS NO: 64354-50-3
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Mol File: 64354-50-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 145-147.5
• Boiling Point: 312.5°C at 760 mmHg
• Flash Point: 142.8°C
• Appearance: /
• Density: 1.215g/cm³
• Vapor Pressure: 0.000224mmHg at 25°C
• Refractive Index: 1.574
• PKA: 4.20±0.26(Predicted)
• CAS DataBase Reference: 5-METHYL-2-PHENYL-3-FUROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PHENYL-3-FUROIC ACID(64354-50-3)
• EPA Substance Registry System: 5-METHYL-2-PHENYL-3-FUROIC ACID(64354-50-3)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 64354-50-3(Hazardous Substances Data)

Usage

General Description

5-METHYL-2-PHENYL-3-FUROIC ACID is a chemical compound with the molecular formula C12H10O3. It is a furoic acid derivative, consisting of a furan ring with a carboxylic acid group and a phenyl group. 5-METHYL-2-PHENYL-3-FUROIC ACID is commonly used in the synthesis of pharmaceuticals and agrochemicals as it exhibits various biological activities. It has also been studied for its potential antitumor and antibacterial properties. 5-METHYL-2-PHENYL-3-FUROIC ACID is a white to off-white crystalline powder and is typically handled and stored in a controlled laboratory environment.

InChI:InChI=1/C12H10O3/c1-8-7-10(12(13)14)11(15-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,13,14)

Upstream product

• 29113-65-3 ethyl 5-methyl-2-phenylfuran-3-carboxylate 
• 62664-60-2 ethyl 2-benzoyl-4-oxopentanoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 34721-89-6 2-methyl-5-phenyl-furan 
• 3810-26-2 3-phenyl-2-cyclopenten-1-one 
• 183210-32-4 5-methyl-2-phenylfuran-3-carbonyl chloride 

Relevant articles and documents

Synthesis, insecticidal activities, and SAR studies of novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives

Diamide compounds such as chlorantraniliprole, a famous anthranilic diamide insecticide targeting the insect ryanodine receptor (RyR), have received continuous attention in pesticide research during the past 15 years owing to their excellent insecticidal potentials. With the aim of discovering new heterocyclic pesticides used for crop protection, based on the structural information of compound M from the reported pharmacophore-based virtual screening for RyR insecticides and diamide compound, a series of new heterocyclic mono-, di-, and tri-amide derivatives containing piperazine moiety have been synthesized in this paper. The new compounds were identified and confirmed by melting point, 1H NMR, 13C NMR and HRMS. Compound M was firstly validated for insecticidal activities, and the new synthesized compounds were all made comprehensive insecticidal evaluations against diamondback moth and oriental armyworm. The bioassay results showed that some of the compounds exhibit favorable insecticidal potentials, particularly some novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives such as 8g, 14a, 15a, 15g, 15i, 15j, 15k, 15l, and 15m could be used as new insecticidal leading structures for further study (e.g., towards diamondback moth, 15i-15m LC50: 0.0022?0.0081 mg/L). The structure-activity relationships of the compounds discussed in detail provide useful guidance for further design and development of new insecticides.