29237-95-4

Basic information

• Product Name: chloro-benzyl amine
• Synonyms: chloro-benzyl amine
• CAS NO: 29237-95-4
• Molecular Weight: 141.6
• Mol File: 29237-95-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: chloro-benzyl amine(CAS DataBase Reference)
• NIST Chemistry Reference: chloro-benzyl amine(29237-95-4)
• EPA Substance Registry System: chloro-benzyl amine(29237-95-4)

Safety Data

• Hazardous Substances Data: 29237-95-4(Hazardous Substances Data)

Upstream product

• 36942-09-3 N,N-dichlorourea 
• 100-46-9 benzylamine 
• 16844-21-6 N-Chlorourethan 
• 52175-97-0 chloro-carbamic acid propyl ester 
• 71-43-2 benzene 
• 7647-01-0 hydrogenchloride 
• 3287-99-8 benzylamine hydrochloride 

Downstream Products

• 1485-70-7 N-benzylbenzamide 
• 7595-68-8 N-benzyl-3-nitrobenzamide 
• 725-38-2 N-benzyl-4-fluorobenzamide 
• 3940-84-9 N-benzyl-3,4,5-trimethoxybenzamide 
• 80311-89-3 4-bromo-N-benzylbenzamide 
• 82082-50-6 N-benzyl-2-bromobenzamide 
• 82082-49-3 N-benzyl-(3-chloro)benzamide 
• 2585-26-4 4-nitro-N-benzylbenzamide 
• 7461-34-9 N-benzyl-p-chlorobenzamide 
• 7465-87-4 N-benzyl-4-methoxybenzamide 
• 5436-83-9 N-benzyl-4-methylbenzamide 
• 7506-50-5 N-(o-chlorobenzoyl)benzylamine 
• 10354-43-5 thiophene-2-carboxylic acid benzylamide 
• 405-81-2 N-benzyl-4-(trifluoromethyl)aniline 

Relevant articles and documents

Two-step continuous flow synthesis of amide via oxidative amidation of methylarene

A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide.

Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C-H activation

A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.

AIBN-initiated metal free amidation of aldehydes using N-chloroamines

An efficient and environmentally benign amidation of aldehydes with N-chloroamines has been developed using AIBN as an initiator. This methodology offers a metal free and base free approach and is endowed with mild reaction conditions, high yields, and good functional group tolerance.