3940-84-9

Basic information

• Product Name: N-benzyl-3,4,5-trimethoxybenzamide
• Synonyms: N-benzyl-3,4,5-trimethoxybenzamide
• CAS NO: 3940-84-9
• Molecular Weight: 301.342
• Mol File: 3940-84-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: N-benzyl-3,4,5-trimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-3,4,5-trimethoxybenzamide(3940-84-9)
• EPA Substance Registry System: N-benzyl-3,4,5-trimethoxybenzamide(3940-84-9)

Safety Data

• Hazardous Substances Data: 3940-84-9(Hazardous Substances Data)

Upstream product

• 3086-62-2 3,4,5-trimethoxybenzamide 
• 100-51-6 benzyl alcohol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 100-46-9 benzylamine 
• 29237-95-4 chloro-benzyl amine 
• 3287-99-8 benzylamine hydrochloride 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 845520-93-6 3-Benzyl-5-methyl-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 845520-95-8 3-Benzyl-6-methyl-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 1430730-44-1 4-benzyl-5-(3,4,5-trimethoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole 
• 1430730-60-1 4-benzyl-5-(β-D-glucopyranosyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazole 
• 1430730-92-9 5-(β-D-glucopyranosyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazoIe 
• 933607-84-2 N-benzyl-3,4,5-trimethoxythiobenzamide 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Relevant articles and documents

N-Benzylbenzamides: A new class of potent tyrosinase inhibitors

A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC50 of 2.2 μM.

N-Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes

A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis cell to oxidize Breslow intermediates. After electrochemical oxidation, the reaction of the intermediate N-acylated thiazolium cation with primary amines is completed by passage through a heating cell to achieve high conversion in a single pass. The flow mixing regimen circumvented the issue of competing imine formation between the aldehyde and amine substrates, which otherwise prevented formation of the desired product. High yields (71-99%), productivities (up to 2.6 g h-1), and current efficiencies (65-91%) were realized for 19 amides.

Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI-TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C-H Activation

A solvent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free radial pathway has been demonstrated. The proposed methodology uses the TBAI-TBHP combination which efficiently induces metal-free C-H activation of aldehydes under neat conditions at 50 °C or ball-milling conditions at room temperature.