2991-28-8 Usage
Description
2,5-Difluorobenzoic acid is a white crystalline powder with chemical properties that make it a versatile compound in various applications. It is characterized by the presence of two fluorine atoms at the 2nd and 5th positions of the benzoic acid molecule, which imparts unique characteristics to the molecule.
Uses
Used in Pharmaceutical Industry:
2,5-Difluorobenzoic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential applications in treating different medical conditions.
Used in Chemical Synthesis:
2,5-Difluorobenzoic acid is used as a building block in the preparation of various organic compounds, including hydrazone derivatives. These derivatives have shown potential as antibacterial agents, making 2,5-difluorobenzoic acid an important component in the development of new antimicrobial substances.
Used in Environmental Analysis:
2,5-Difluorobenzoic acid has been detected and quantified in groundwater samples using liquid chromatography-tandem mass spectrometry. This indicates its use in environmental monitoring and analysis, helping to assess the presence and impact of this compound in natural water sources.
Used in Material Science:
The unique properties of 2,5-difluorobenzoic acid make it a candidate for use in the development of new materials with specific characteristics, such as improved stability or enhanced chemical reactivity. Its application in material science can lead to the creation of novel materials with a wide range of potential uses.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 28, p. 1864, 1985 DOI: 10.1021/jm00150a018
Check Digit Verification of cas no
The CAS Registry Mumber 2991-28-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,9 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2991-28:
(6*2)+(5*9)+(4*9)+(3*1)+(2*2)+(1*8)=108
108 % 10 = 8
So 2991-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F2O2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)/p-1
2991-28-8Relevant articles and documents
Proton transfer equilibria between disubstituted benzoic acids and carbinol base of crystal violet in apolar aprotic solvents. Chemometric analysis of disubstituent effects on the strength of benzoic acid in chlorobenzene
Sen Gupta, Susanta K.,Shrivastava, Ruchi
, p. 369 - 373 (2008/09/19)
Proton transfer equilibria in chlorobenzene between a set of di-substituted (2,3-,2,5-,2,6-, 3,5-dichloro and difluoro) benzoic acids including the corresponding mono-substituted acids and the carbinol base of crystal violet have been studied spectrophotometrically. To investigate the effect of disubstitution at ortho- and/or meta- positions on the strength of benzoic acid, the results have been analysed chemometrically on the basis of Fujita Nishioka's multiparameter approach and the assumption of additivity for substituent effects. The model employed explains 94% of the variance for the disubstituent effects on log K. It is observed that the substituent effect is contributed by ordinary electronic and proximity electronic effects in an almost equal ratio (52:48).
Process for the preparation of fluorinated benzoic acids
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, (2008/06/13)
In the process for the preparation of fluorinated benzoic acids of the formula I STR1 in which X and Y, for example, independently of one another denote chlorine or fluorine and X moreover denotes bromine, a fluorinated chloroacetophenone of the formula II STR2 in which Z denotes chlorine or hydrogen, is reacted with a hypohalite.
Synthesis of 1-fluoro-, 4-fluoro-, and 1,4-difluoro-4-demethoxydaunomycinone. Interesting D-ring analogues of adriamycin
Morrow,Swenton,Filppi,Wolgemuth
, p. 713 - 719 (2007/10/02)
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