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inquiry2,5-Difluorobenzoic acid 2991-28-8 2,5-Difluorobenzoic acid Basic information Product Name: 2,5-Difluorobenzoic acid Synonyms: 2,5-DIFLUOROBENZOIC ACID;RARECHEM AL BO 0019;Benzoic acid
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inquiryName: 2,5-Difluorobenzoic acid CAS:2991-28-8 MF: C7H4F2O2 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:APIs Transportation:By sea or by air Port:Qingdao Port
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name: 2,5-Difluorobenzoic acid Synonyms: 2,5-DIFLUOROBENZOIC ACID;RARECHEM AL BO 0019;Benzoic acid, 2,5-difluoro-;2,5-Difluorobenzic acid;2-chloro-6-flurobenzyl cyanide;2,5-Difluorobenzoic;2,5-Difluorobenzoic acid 98%;2,5-Difluorobenzoi
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inquiry2,5-Difluorobenzoic acid CAS:2991-28-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: 2,5-Difluorobenzoic Acid CAS No.: 2991-28-8 Molecule Formula:C7H3F2O2 Molecule Weight:157.09 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
Conditions | Yield |
---|---|
With n-butyllithium 1) hexane, Et2O, 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With sec.-butyllithium 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 15 min, b) from -78 deg C to RT; Yield given. Multistep reaction; |
2,3,6-trifluorobenzoic acid
A
3-fluorobenzoic acid
B
benzoic acid
C
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With ammonia; sodium at -45℃; for 0.25h; Reduction; Hydrodefluorination; Title compound not separated from byproducts; | A 9 % Spectr. B 9 % Spectr. C 16 % Spectr. |
Conditions | Yield |
---|---|
With potassium permanganate Oxidation; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: KMnO4 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: BuLi / tetrahydrofuran / -70 °C 1.2: tetrahydrofuran 2.1: 9 percent Spectr. / Zn; NH3 / -45 °C 3.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: BuLi / tetrahydrofuran / -70 °C 1.2: tetrahydrofuran 2.1: 12 percent Spectr. / Na; NH3 / 0.25 h / -45 °C 3.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BuLi / tetrahydrofuran / -70 °C 1.2: tetrahydrofuran 2.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme |
2,3,4,6-tetrafluorobenzoic acid
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 9 percent Spectr. / Zn; NH3 / -45 °C 2: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme | |
Multi-step reaction with 2 steps 1: 12 percent Spectr. / Na; NH3 / 0.25 h / -45 °C 2: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme |
Conditions | Yield |
---|---|
With hydrogenchloride In sodium hypobromide; water |
Conditions | Yield |
---|---|
With water In chlorobenzene at 28℃; Equilibrium constant; Further Variations:; Temperatures; |
2,5-difluorobenzoic acid
2,5-difluorobenzoyl chloride
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h; Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h; | 100% |
With thionyl chloride Heating; | 97% |
With sulfuryl dichloride for 4h; Heating; | 73% |
Conditions | Yield |
---|---|
With sulfuric acid at 100℃; for 12h; Sealed tube; | 95% |
With sulfuric acid Reflux; | |
With sulfuric acid for 10h; Reflux; |
2,5-difluorobenzoic acid
4,7-difluoro-3-hydroxy-1(3H)-isobenzofuranone
Conditions | Yield |
---|---|
With sec-BuLi In tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide | 93% |
With sec-BuLi In tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide | 93% |
Multi-step reaction with 5 steps 1: 73 percent / SO2Cl / 4 h / Heating 2: CH2Cl2 / 6 h / Ambient temperature 3: SOCl2 / 12 h 4: 1.) sec-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h 5: 5 N HCl / Heating View Scheme |
Conditions | Yield |
---|---|
In ethanol; toluene byproducts: acetic acid; equimolar amts. of Sn-compd. and the benzoic acid are mixed with toluene/EtOH (3:1), mixt. refluxed (4 h); the azeotrope acetic acid/EtOH/toluene followed by the azeotrop toluene/EtOH is distilled off to 50% of the initial vol., evapn. (reduced pressure); | 92% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide | 91% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 3h; | |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In tetrahydrofuran; N,N-dimethyl-formamide for 16h; |
2,5-difluorobenzoic acid
N-t-Butyl-2,5-difluorobenzamide
Conditions | Yield |
---|---|
91% |
Conditions | Yield |
---|---|
In methanol; acetone at 60℃; for 1h; | 91% |
Conditions | Yield |
---|---|
With thionyl chloride Reflux; | 90.7% |
With sulfuric acid for 12h; Reflux; | 66% |
With thionyl chloride at 60℃; for 3h; Cooling with ice; |
2-(3,4-bis(benzyloxy)phenyl)-7-(benzyloxy)-3,5-dihydroxy-4H-chromen-4-one
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 50℃; for 5h; | 84% |
oridonin
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane | 83% |
tert-butyl alcohol
2,5-difluorobenzoic acid
N-(tert-Butoxycarbonyl)-2,5-difluoroaniline
Conditions | Yield |
---|---|
With diphenylphosphoranyl azide; triethylamine for 2h; Heating; | 81% |
methyl 2-diazohydrocinnamate
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With C2HF6NO4S2*C27H30BNO In dichloromethane at -78℃; for 1h; Inert atmosphere; enantioselective reaction; | A 75% B n/a |
2,5-difluorobenzoic acid
2,5-difluoro-3-nitro-benzoic acid
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid | 72% |
With sulfuric acid; nitric acid at 0 - 20℃; for 1h; | 31.3% |
With sulfuric acid; nitric acid In water at 0 - 20℃; | 31.3% |
With sulfuric acid; nitric acid at 0 - 20℃; | 31.3% |
With sulfuric acid; nitric acid at 0 - 20℃; | 31.3% |
5-(propylthio)-1H-benzimidazol-2-ylamine
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With potassium carbonate; 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.5h; Stage #2: 5-(propylthio)-1H-benzimidazol-2-ylamine In tetrahydrofuran Reflux; | 71% |
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; potassium acetate; dichloro[η5-1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(2,3,4,5-tetramethylcyclopentadienyl)ethyl)urea][(6-oxo-1,6-dihydropyridin-2-yl)diphenylphosphine]rhodium(III); copper(II) trifluoroacetate In toluene at 120℃; for 16h; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 70% |
4-pyridin-2-yl-thiazol-2-ylamine
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 23℃; for 0.5h; Inert atmosphere; Stage #2: 4-pyridin-2-yl-thiazol-2-ylamine In N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere; | 69% |
Conditions | Yield |
---|---|
Stage #1: [Ru2II,III(CH3CO2)4(THF)2]BF4; 2,5-difluorobenzoic acid In N,N-dimethyl-aniline for 12h; Schlenk technique; Glovebox; Reflux; Stage #2: tetrahydrofuran | 67% |
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Stage #2: {2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine In dichloromethane at 20℃; for 1h; | 65% |
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 64% |
5-chloro-2-benzoxazolinone
2,5-difluorobenzoic acid
5-chloro-6-(2,5-difluoro-benzoyl)-3H-benzooxazol-2-one
Conditions | Yield |
---|---|
With PPA Acylation; | 62% |
N-(2-methylbenzoyl)-8-aminoquinoline
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With sodium carbonate In N,N-dimethyl acetamide at 110℃; for 0.5h; Schlenk technique; Inert atmosphere; Stage #2: N-(2-methylbenzoyl)-8-aminoquinoline With nickel(II) acetate tetrahydrate; silver nitrate In N,N-dimethyl acetamide at 170℃; for 24h; Schlenk technique; Inert atmosphere; | 62% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h; | 62% |
tetraacetyl thioglucose
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With copper acetylacetonate; silver carbonate at 130℃; for 0.25h; Microwave irradiation; Inert atmosphere; Sealed tube; stereoselective reaction; | 62% |
Conditions | Yield |
---|---|
With sulfuric acid; magnesium sulfate In toluene at 20℃; Sealed tube; | 62% |
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h; | 59% |
2-Benzoxazolinone
2,5-difluorobenzoic acid
6-(2,5-difluoro-benzoyl)-3H-benzooxazol-2-one
Conditions | Yield |
---|---|
With PPA Acylation; | 58% |
With PPA | |
With PPA at 140 - 160℃; |
2,5-difluorobenzoic acid
2,5-difluorobenzohydrazide
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With thionyl chloride In dichloromethane at 20℃; Reflux; Stage #2: With hydrazine In dichloromethane for 4h; Reflux; | 56% |
Multi-step reaction with 2 steps 1: sulfuric acid / Reflux 2: hydrazine hydrate / ethanol / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid / 10 h / Reflux 2: hydrazine hydrate / ethanol / 8 h / Reflux View Scheme |
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (Z)-N′-hydroxy-1H-benzo[d]imidazole-5-carboximidamide In N,N-dimethyl-formamide at 110℃; | 47.6% |
2,5-difluorobenzoic acid
Conditions | Yield |
---|---|
With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 70℃; for 6h; | 39.5% |
N-biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride
2,5-difluorobenzoic acid
N-Biphenyl-4-yl-3-[4-(2,5-difluoro-benzoyl)-piperazin-1-yl]-3-oxo-propionamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 10 - 20℃; | 37% |
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