305371-17-9 Usage
General Description
6-fluoro-4-hydroxy-1,7-naphthyridine-3-carbonitrile is a chemical compound that belongs to the class of naphthyridine derivatives. It is characterized by the presence of a fluorine atom, a hydroxy group, and a carbonitrile functional group on the naphthyridine ring. 6-fluoro-4-hydroxy-1,7-naphthyridine-3-carbonitrile has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals. Its unique structure and properties make it an interesting target for further research and exploration for potential uses in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 305371-17-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,5,3,7 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 305371-17:
(8*3)+(7*0)+(6*5)+(5*3)+(4*7)+(3*1)+(2*1)+(1*7)=109
109 % 10 = 9
So 305371-17-9 is a valid CAS Registry Number.
305371-17-9Relevant articles and documents
Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles
Wissner, Allan,Hamann, Philip R.,Nilakantan, Ramaswamy,Greenberger, Lee M.,Ye, Fei,Rapuano, Timothy A.,Loganzo, Frank
, p. 1411 - 1416 (2007/10/03)
The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.
SUBSTITUTED 3-CYANO-[1.7], [1.5] AND [1.8] NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES
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Page column 65, (2010/02/05)
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