305800-58-2

Basic information

• Product Name: 3-Bromo-5-fluorophenylacetonitrile
• Synonyms: 3-Bromo-5-fluorophenylacetonitrile;2-(3-Bromo-5-fluorophenyl)acetonitrile;3-Bromo-5-fluorobenzyl cyanide
• CAS NO: 305800-58-2
• Molecular Formula: C₈H₅BrFN
• Molecular Weight: 214.0344032
• Mol File: 305800-58-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 277.9±25.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.573±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-Bromo-5-fluorophenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-fluorophenylacetonitrile(305800-58-2)
• EPA Substance Registry System: 3-Bromo-5-fluorophenylacetonitrile(305800-58-2)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 305800-58-2(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-fluorophenylacetonitrile is a chemical compound with the formula C8H5BrFNO. It is a white to off-white solid that is primarily used as an intermediate in the synthesis of pharmaceutical compounds. 3-Bromo-5-fluorophenylacetonitrile is a nitrile, which means it contains a carbon-nitrogen triple bond, and it has both bromine and fluorine substituents on the phenyl ring. It is also a versatile building block for the construction of complex molecules, making it valuable in the pharmaceutical and chemical industries. This chemical has the potential to be a highly reactive and useful reagent for the development of new drugs and other biologically active compounds.

Upstream product

• 216755-57-6 1-bromo-3-(bromomethyl)-5-fluorobenzene 
• 176548-70-2 3-bromo-5-fluorobenzoic acid 
• 216755-56-5 5-fluoro-3-hydroxymethylbromobenzene 
• 773837-37-9 sodium cyanide 

Downstream Products

• 305800-59-3 3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]-oxazin-6-yl)-5-fluoro-phenylacetonitrile 
• 1035346-57-6 tert-butyl 4-(3-bromo-5-fluorophenyl)-4-cyanopiperidine-1-carboxylate 
• 1159186-73-8 (2S,4S)-4-(3-bromo-5-fluorophenyl)-2-methyl-tetrahydro-2H-pyran-4-carbonitrile 
• 1159186-72-7 (2S,4R)-4-(3-bromo-5-fluorophenyl)-2-methyl-tetrahydro-2H-pyran-4-carbonitrile 

Relevant articles and documents

ANTI-EGFR ANTIBODY DRUG CONJUGATES

The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION

Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include promoting tissue self-repair or tissue regeneration of an organ, stimulating the generation of tissue growth, modulating (e.g. increasing) the level of a tissue-repair marker, treating physical injury in an organ, tissue, or cell, promoting wound healing as well as anti-aging applications. Corresponding compositions, methods and uses are also described. Formula I wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F of OH; R2 is H, F, OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH, or CH2Ph; R4 is H, F or OH; Q is 1) (CH2),C(0)OH wherein m is 1 or 2 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH or 6) C(0)-C(0)OH.

QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.