3108-34-7Relevant articles and documents
Highly Enantioselective [3 + 2] Annulation of 3-Butynoates with β-Trifluoromethyl Enones Promoted by an Amine-Phosphine Binary Catalytic System
Ding, Kuiling,Han, Zhaobin,Lu, Yixin,Ni, Huanzhen,Wong, Yee Lin,Wu, Mingyue
, (2020/03/30)
We report a highly enantioselective [3 + 2] annulation between 3-butynoates and β-trifluoromethyl enones, furnishing trifluoromethylated cyclopentenes with three contiguous stereogenic centers in good yields, high diastereoselectivities, and excellent enantioselectivities. A unique catalytic system consisting of a simple amine and a chiral phosphine was devised, and the synergistic play of Lewis basic amine and phosphine was crucial for alkyne isomerization and subsequent cyclization. The protocol disclosed herein allows facile activation of 3-butynoates in phosphine-mediated asymmetric transformations.
Preparation method of (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound
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Paragraph 0054-0056; 0108-0173, (2020/03/02)
The invention discloses a preparation method of an (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound, and belongs to the field of compound preparation. The (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound is prepared by taking a compound shown
Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones
Ramasamy, Manickavasakam,Lin, Hui-Chang,Kuo, Sheng-Chu,Hsieh, Min-Tsang
, p. 356 - 360 (2019/02/12)
A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi