31085-55-9Relevant articles and documents
COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1
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Paragraph 246; 247, (2019/05/15)
The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.
CYCLIC DINUCLEOTIDES AS STING AGONISTS
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Page/Page column 130; 132, (2018/08/20)
Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B
First synthesis of 2'-deoxyfluoropuromycin analogues: Experimental insight into the mechanism of the staudinger reaction
Charafeddine, Adib,Dayoub, Wissam,Chapuis, Hubert,Strazewski, Peter
, p. 5566 - 5584 (2008/02/12)
The N6, N6-dedimethyl-2'-deoxyfluoro analogue of puromycin (= 3'-deoxy-N6, N6-dimethyl-3'- [Omethyltyrosylamido]adenosine), its 2',3'-regioisomer and a 3'-cytidyl-5'-(2'deoxyfluoro)puromycyl dinucleotide analogu