310886-79-4

Basic information

• Product Name: 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER
• Synonyms: RARECHEM AL BF 0942;5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER;METHYL 5-FLUORO-1H-INDOLE-3-CARBOXYLATE;1H-Indole-3-carboxylic acid, 5-fluoro-, Methyl ester
• CAS NO: 310886-79-4
• Molecular Formula: C10H8FNO2
• Molecular Weight: 193.17
• Product Categories: pharmacetical
• Mol File: 310886-79-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 200-202℃
• Boiling Point: 335.3 °C at 760 mmHg
• Flash Point: 156.6 °C
• Appearance: /
• Density: 1.341±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000121mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER(310886-79-4)
• EPA Substance Registry System: 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER(310886-79-4)

Safety Data

• Hazardous Substances Data: 310886-79-4(Hazardous Substances Data)

Usage

General Description

5-Fluoro-1H-indole-3-carboxylic acid methyl ester is a chemical compound that is derived from the indole family. It is a methyl ester of 5-fluoro-1H-indole-3-carboxylic acid and is commonly used in the synthesis of pharmaceuticals and organic compounds. This chemical has a fluorine atom attached to the indole ring, which can affect its reactivity and pharmacological properties. It is often used as a building block in the synthesis of diverse natural and synthetic bioactive compounds with potential therapeutic applications. 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER has attracted attention in the field of medicinal chemistry due to its versatile reactivity and potential utility in drug design and development.

InChI:InChI=1/C10H8FNO2/c1-14-10(13)8-5-12-9-3-2-6(11)4-7(8)9/h2-5,12H,1H3

Upstream product

• 67-56-1 methanol 
• 23077-43-2 5-fluoro-1H-indole-3-carboxylic acid 
• 399-52-0 5-fluoro-1H-indole 
• 76-02-8 trifluoroacetyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 407-25-0 trifluoroacetic anhydride 
• 578703-92-1 methyl 1-(4-fluorophenyl)-1H-1,2,3-triazole-4-carboxylate 
• 21880-95-5 (Z)-methyl 3-((4-fluorophenyl)amino)acrylate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1072009-08-5 5-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 

Relevant articles and documents

Palladium-catalyzed oxidative coupling of aromatic primary amines and alkenes under molecular oxygen: Stereoselective assembly of (Z)-enamines

An efficient Pd-catalyzed oxidative coupling of aromatic primary amines and alkenes under molecular oxygen is disclosed. Under mild reaction conditions, it provides a rapid access to (Z)-enamine compounds with exceptional functional group tolerance and ex

THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS

The invention provides a compound which is a quinazoline of formula (I): and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over other class Ia PI3 kinases and