31309-08-7

Basic information

• Product Name: 2-CHLORO-5-NITRONICOTINONITRILE
• Synonyms: 2-Chloro-5-nitronicotinonitrile;2-Chloro-3-cyano-5-nitropyridine;2-Chloro-5-nitropyridine-3-carbonitrile;2-Chloro-5-nitropyridine-3-carbonitrile 97%
• CAS NO: 31309-08-7
• Molecular Formula: C₆H₂ClN₃O₂
• Molecular Weight: 183.55
• Mol File: 31309-08-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 121-126°C
• Boiling Point: 312.4 °C at 760 mmHg
• Flash Point: 142.8 °C
• Appearance: /
• Density: 1.57 g/cm³
• Vapor Pressure: 0.000529mmHg at 25°C
• Refractive Index: 1.603
• PKA: -6.54±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-NITRONICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-NITRONICOTINONITRILE(31309-08-7)
• EPA Substance Registry System: 2-CHLORO-5-NITRONICOTINONITRILE(31309-08-7)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• RIDADR: UN 3439 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 31309-08-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-nitronicotinonitrile is a chemical compound with the molecular formula C6H2ClN3O2. It is a nitro-containing compound that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. This chemical is utilized in the pharmaceutical industry for the production of drugs and in the agrochemical industry for the manufacturing of pesticides and herbicides. It is also used as a starting material in the synthesis of various organic compounds with nitrogen-containing functional groups. 2-Chloro-5-nitronicotinonitrile is a versatile building block that has applications in various industries due to its reactivity and ability to undergo different chemical reactions.

InChI:InChI=1/C6H2ClN3O2/c7-6-4(2-8)1-5(3-9-6)10(11)12/h1,3H

Upstream product

• 135795-55-0 2-chloro-3-chlorocarbonyl-5-nitropyridine 
• 60524-15-4 2-chloro-5-nitronicotinamide 
• 10128-92-4 2-hydroxynicotinamide 
• 941083-49-4 C₆H₅N₃O₄ 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 20577-27-9 2-hydroxy-3-cyanopyridine 
• 31309-38-3 2-hydroxy-5-nitronicotinonitrile 

Downstream Products

• 293735-69-0 5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine 
• 180424-13-9 2-[(β-hydroxyethyl)amino]-3-cyano-5-nitropyridine 
• 180424-17-3 2-[(di-β-hydroxyethyl)amino]-3-cyano-5-nitropyridine 
• 293735-80-5 8-nitro-3-phenylpyrido[3',2':4,5]thieno[3.2-d]pyrimidin-4(3H)-one 
• 293735-70-3 3-amino-5-nitro-2-(N-phenylaminocarbonyl)thieno[2,3-b]pyridine 
• 52505-43-8 2-ethoxycarbonyl-3-amino-5-nitrothieno[2,3-b]pyridine 
• 208454-27-7 2-phenyloxy-3-cyano-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 6854-07-5 2-hydroxy-5-nitropyridine-3-carboxylic acid 

Relevant articles and documents

-

-

New 2-Thiopyridines as potential candidates for killing both actively growing and dormant mycobacterium tuberculosis cells

From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attempts, no specific antimicrobials effective against latent tuberculosis have yet been found, partly because of a lack of reliable and adequate in vitro models for screening of drug candidates. We propose here a novel in vitro model of M. tuberculosis dormancy that meets the important criteria of latency, namely, nonculturability of cells, considerable reduction of metabolic activity, and significant phenotypic resistance to the first-line antibiotics rifampin and isoniazid. Using this model, we found a new group of 2-thiopyridine derivatives that had potent antibacterial activity against both actively growing and dormant M. tuberculosis cells. By means of the model of M. tuberculosis nonculturability, several new 2-thiopyridine derivatives were found to have potent antitubercular activity. The compounds are effective against both active and dormant M. tuberculosis cells. The bactericidal effects of compounds against dormant M. tuberculosis was confirmed by using three different in vitro models of tuberculosis dormancy. The model of nonculturability could be used as a reliable tool for screening drug candidates, and 2-thiopyridine derivatives may be regarded as prominent compounds for further development of new drugs for curing latent M. tuberculosis infection.