6602-54-6 Usage
Description
2-Chloro-3-cyanopyridine, with the CAS number 6602-54-6, is a white to light yellow crystal powder that serves as a versatile compound in the realm of organic synthesis. Its unique chemical structure, featuring a chlorine atom at the 2nd position and a cyano group at the 3rd position on the pyridine ring, endows it with a range of reactivity and potential applications in various chemical processes.
Uses
Used in Organic Synthesis:
2-Chloro-3-cyanopyridine is used as a key intermediate for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its chemical properties allow it to participate in a wide array of reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and cross-coupling reactions, making it a valuable building block in the development of complex molecular structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-3-cyanopyridine is utilized as a starting material for the synthesis of novel drug candidates with potential therapeutic applications. Its unique structural features enable the creation of diverse chemical entities that can target specific biological receptors or enzymes, contributing to the discovery of new medicines for various diseases.
Used in Agrochemical Industry:
2-Chloro-3-cyanopyridine also finds application in the agrochemical industry, where it is employed in the synthesis of new pesticides, herbicides, and insecticides. Its reactivity and structural diversity allow for the development of innovative compounds that can effectively control pests and diseases in agriculture, ensuring increased crop yield and food security.
Used in Chemical Research:
In the field of chemical research, 2-Chloro-3-cyanopyridine serves as a valuable compound for exploring new reaction mechanisms, understanding structure-activity relationships, and developing new synthetic methodologies. Its unique properties make it an attractive candidate for studying various aspects of organic chemistry, including reaction kinetics, stereochemistry, and catalysis.
Check Digit Verification of cas no
The CAS Registry Mumber 6602-54-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,0 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6602-54:
(6*6)+(5*6)+(4*0)+(3*2)+(2*5)+(1*4)=86
86 % 10 = 6
So 6602-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClN2/c7-6-5(4-8)2-1-3-9-6/h1-3H
6602-54-6Relevant articles and documents
Preparation method of 2- novel chloronicotinic acid (by machine translation)
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Paragraph 0041-0044, (2020/02/14)
The method disclosed by the invention 2 - comprises the following steps: reacting the obtained :1) product with trichlorooxygen phosphorus, in the presence of 1) an acid, to give 2 - the product of 2 - the present invention ;2) in the following steps: reacting the obtained product with phosphorus oxychloride, in 2 - the presence of a ;3) base with 2) phosphorus oxychloride in the presence of a base, 2 - 2 . (by machine translation)
2-chloro-3-cyanopyridine preparation process
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Paragraph 0016-0021; 0023; 0025, (2019/04/04)
The invention provides a 2-chloro-3-cyanopyridine preparation process which includes the steps: dissolving N-oxynicotinamide in an organic solvent; dripping phosphorus oxychloride at the temperature of 15+/-5 DEG C; dripping organic alkali at the temperature of 10+/-5 DEG C after dripping; keeping the temperature of 10+/-5 DEG C to stir mixture for 30+/-10 minutes after dripping; heating the mixture to reach the temperature of 35+/-10 DEG C, and keeping the temperature for 1+/-0.5 hour; heating the mixture to reach the temperature of 55+/-5 DEG C, and keeping the temperature for 1+/-0.5 hour;heating the mixture to reach the temperature of 95-100 DEG C, and keeping the temperature for 4+/-1 hours to obtain chloride reaction solution after temperature keeping; performing reduced pressure distillation on the chloride reaction solution until flow out of visible liquid is omitted; adding water, controlling the temperature to reach 65+/-5 DEG C, and stirring mixture for 2+/-0.5 hour; cooling the mixture to reach the temperature of 20+/-5 DEG C, stirring the mixture for 30+/-10 minutes, and filtering the mixture to obtain a wet 2-chlorine-3-cyanopyridine product. According to the process, two mixed organic alkali substances serve as catalysts, and the yield of 2-chlorine-3-cyanopyridine is improved to some extent.
Combining Oxoammonium Cation Mediated Oxidation and Photoredox Catalysis for the Conversion of Aldehydes into Nitriles
Nandi, Jyoti,Witko, Mason L.,Leadbeater, Nicholas E.
supporting information, p. 2185 - 2190 (2018/09/29)
A method to oxidize aromatic aldehydes to nitriles has been developed. It involves a dual catalytic system of 4-acetamido-TEMPO and visible-light photoredox catalysis. The reaction is performed using ammonium persulfate as both the terminal oxidant and nitrogen source.