31788-88-2

Basic information

• Product Name: (2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE
• Synonyms: TIMTEC-BB SBB010174;N2,N2-DIMETHYL-1-PHENYL-ETHANE-1,2-DIAMINE;N-(2-AMINO-2-PHENYLETHYL)-N,N-DIMETHYLAMINE;(2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE;ASINEX-REAG BAS 09615094;beta-Amino-N,N-dimethylphenethylamine;DL-(2-AMino-2-phenylethyl)diMethylaMine;N1,N1-Dimethyl-2-phenylethane-1,2-diamine
• CAS NO: 31788-88-2
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.25
• Mol File: 31788-88-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 238.2 °C at 760 mmHg
• Flash Point: 91.2 °C
• Appearance: /
• Density: 0.983 g/cm³
• Vapor Pressure: 0.0429mmHg at 25°C
• PKA: 9.88±0.10(Predicted)
• CAS DataBase Reference: (2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE(31788-88-2)
• EPA Substance Registry System: (2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE(31788-88-2)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 31788-88-2(Hazardous Substances Data)

Usage

General Description

(2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE is a chemical compound with the formula C10H15N. It is an organic amine, specifically a secondary amine, which consists of a dimethylamine moiety substituted by a 2-phenylethyl group. It is used in various industrial and pharmaceutical applications, including as a building block for the synthesis of other compounds. This chemical is an important intermediate in the production of pharmaceuticals and agrochemicals. Additionally, it is also used in research and development for potential new applications.

InChI:InChI=1/C10H16N2/c1-12(2)8-10(11)9-6-4-3-5-7-9/h3-7,10H,8,11H2,1-2H3/p+2/t10-/m0/s1

Upstream product

• 3319-03-7 2-dimethylamino-1-phenyl-ethanone 

Downstream Products

• 95646-38-1 1-methyl-4-phenyl-imidazolidine 
• 95646-39-2 N-(2-Amino-2-phenyl-ethyl)-N-methyl-formamide 
• 95646-42-7 1-Methyl-4-phenyl-4,5-dihydro-1H-imidazole 
• 20537-03-5 1-(2-Acetylamino-2-phenyl-ethyl)dimethylamin 
• 95646-40-5 N-(2-Methylamino-1-phenyl-ethyl)-acetamide 
• 95646-41-6 N-[2-(Formyl-methyl-amino)-1-phenyl-ethyl]-acetamide 

Relevant articles and documents

α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain.