31792-47-9

Basic information

• Product Name: 2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: IFLAB-BB F0239-1084;AKOS B000575;AKOS BBS-00000715;AKOS BB-9096;2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID;2-THIEN-2-YLQUINOLINE-4-CARBOXYLIC ACID;2-(2-THIENYL)-4-QUINOLINECARBOXYLIC ACID;TIMTEC-BB SBB007348
• CAS NO: 31792-47-9
• Molecular Formula: C₁₄H₉NO₂S
• Molecular Weight: 255.29
• Mol File: 31792-47-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 211 °C(Solv: ethanol (64-17-5))
• Boiling Point: 458.1 °C at 760 mmHg
• Flash Point: 230.8 °C
• Appearance: /
• Density: 1.386 g/cm³
• Vapor Pressure: 3.47E-09mmHg at 25°C
• Refractive Index: 1.712
• PKA: 0.93±0.10(Predicted)
• CAS DataBase Reference: 2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID(31792-47-9)
• EPA Substance Registry System: 2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID(31792-47-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 31792-47-9(Hazardous Substances Data)

Usage

General Description

2-Thiophen-2-yl-quinoline-4-carboxylic acid is a chemical compound that consists of a quinoline ring fused with a thiophene ring and a carboxylic acid group. It is a heterocyclic compound with potential biological and pharmacological activities. The presence of the thiophene and quinoline moieties in the structure of this compound could endow it with various biological properties, making it potentially useful in medicinal chemistry for the development of new drugs. Additionally, the carboxylic acid group allows for the compound to be easily modified and used as a building block for the synthesis of other organic molecules. Overall, 2-Thiophen-2-yl-quinoline-4-carboxylic acid is a versatile chemical compound with potential applications in pharmaceutical research and drug development.

InChI:InChI=1/C14H9NO2S/c16-14(17)10-8-12(13-6-3-7-18-13)15-11-5-2-1-4-9(10)11/h1-8H,(H,16,17)

Upstream product

• 88-15-3 2-Acetylthiophene 
• 91-56-5 indole-2,3-dione 
• 78660-85-2 3-hydroxy-3-(2-oxo-2-(thiophen-2-yl)ethyl)indolin-2-one 
• 6165-68-0 thiophene boronic acid 
• 5467-57-2 2-chloroquinoline-4-carboxylic acid 

Downstream Products

• 34243-33-9 2-thiophen-2-yl-quinoline 
• 40619-51-0 5-(4-N-Phenylcarboxamido-2-chinolyl)thiophen 
• 39072-28-1 2-(thiophen-2-yl)quinoline-4-carbohydrazide 
• 39078-34-7 2-thiophen-2-yl-quinoline-4-carboxylic acid benzylidenehydrazide 
• 39072-25-8 2-thiophen-2-yl-quinoline-4-carboxylic acid (4-methoxy-benzylidene)-hydrazide 
• 39072-26-9 2-thiophen-2-yl-quinoline-4-carboxylic acid (4-dimethylamino-benzylidene)-hydrazide 
• 39078-35-8 2-thiophen-2-yl-quinoline-4-carboxylic acid (2-nitro-benzylidene)-hydrazide 
• 39072-18-9 2-thiophen-2-yl-quinoline-4-carboxylic acid (4-nitro-benzylidene)-hydrazide 
• 39078-36-9 2-thiophen-2-yl-quinoline-4-carboxylic acid (3-nitro-benzylidene)-hydrazide 
• 39072-27-0 2-thiophen-2-yl-quinoline-4-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-benzylidene}-hydrazide 
• 40619-52-1 2-(5-nitro-thiophen-2-yl)-quinoline-4-carboxylic acid anilide 
• 326870-59-1 N-[2-chloro-5-(trifluoromethyl)phenyl]-2-(thiophen-2-yl)quinoline-4-carboxamide 

Relevant articles and documents

Synthesis and pharmacological properties of some quinoline derivatives

A series of 2-(2-thienyl)cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-b]- 1,3,4-thiaziazolo-6-yl)-2-(2-thienyl)quinolines 6 were synthesized. The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active.

Synthesis of Novel Quinoline–Benzoxazolinone Ester Hybrids: In Vitro Anti-Inflammatory Activity and Antibacterial Activity

Abstract: A series of novel quinoline-benzoxazolinone ester hybrids were synthesized characterized and assessed for their in vitro anti-inflammatory and antibacterial activity. The in vitro anti-inflammatory activity was executed using protein denaturation assay, proteinase inhibitory assay and human red blood cell membrane stabilization assay. Most of the compounds exhibited potential anti-inflammatory activity. Compound (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(thiophen-2-yl)quinoline-4-carboxylate showed a better anti-inflammatory activity than the standard drugs diclofenac sodium and indomethacin. Furthermore, antibacterial activities of the synthesized compounds were evaluated using resazurin microtiter assay (REMA) and were compared with a positive drug standard chloramphenicol. The compounds demonstrated moderate to potent antibacterial activity. (2-Oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(3,4-dimethoxyphenyl)quinoline-4-carboxylate and (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(2-chlorophenyl)quinoline-4-carboxylate displayed excellent activity against all bacterial strains in comparison to standard chloramphenicol. Moreover, cytotoxicity was performed on MDCK cells using MTT assay and it was found that none of the synthesized derivatives possessed any cytotoxicity.

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity

SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Structure-activity relationship analyses led to the identific